Involvement of the SCF complex in the control of Cdh1 degradation in S-phase

被引：51

作者：

Benmaamar, R ^{[1
]}

Pagano, M ^{[1
]}

机构：

[1] NYU, Sch Med, Dept Pathol, New York, NY USA

来源：

CELL CYCLE | 2005年 / 4卷 / 09期

基金：

美国国家卫生研究院;

关键词：

Cdh1; Cul1; SCF; S-phase; degradation;

D O I：

10.4161/cc.4.9.2048

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The anaphase promoting complex/cyclosome (APC/C) is a multisubunit ubiquitin ligase that acts as a key regulator in the progression through mitosis ( when mostly in complex with Cdc20) and as a stabilizer of the G(1) phase ( when in complex with Cdh1). Cdh1 is an activator of APC/C, and it has previously been reported that it is capable of mediating its own degradation during Go and G1. Herein, we show that the SCF complex ( Skp1/Cul1/F-box protein/Roc1) intervenes in the surveillance of Cdh1 cellular abundance in S-phase.

引用

页码：1230 / 1232

页数：3

共 16 条

[1]

ANG XL, 2004, SCI STKE, pPE31

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