The function of APC/CCdh1 in cell cycle and beyond

被引：88

作者：

Li, Min ^{[1
]}

Zhang, Pumin ^{[1
,2
]}

机构：

[1] Baylor Coll Med, Dept Mol Physiol & Biophys, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Biochem & Mol Biol, Houston, TX 77030 USA

来源：

CELL DIVISION | 2009年 / 4卷

关键词：

ANAPHASE-PROMOTING COMPLEX; ETS-2 TRANSCRIPTION FACTORS; CHECKPOINT PROTEIN MAD2; S-PHASE; COMPLEX/CYCLOSOME APC/C; DEPENDENT DEGRADATION; CHROMATID SEPARATION; CHROMOSOME ALIGNMENT; DNA-REPLICATION; GENE-EXPRESSION;

D O I：

10.1186/1747-1028-4-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The anaphase promoting complex/cyclosome (APC/C) is a multi-subunit E3 ubiquitin ligase playing essential functions in mitosis. It is conserved from yeast to human and relies on two adaptor proteins, Cdc20 and Cdh1, to bring in substrates. Both APC(Cdc20) and APC(Cdh1) are implicated in the control of mitosis through mediating ubiquitination and degradation of important mitotic regulators such as cyclin B1, securin, and Plk1. In addition, APC(Cdh1) is thought to prevent premature S phase entry by limiting the accumulation of mitotic cyclins in G1 and to regulate processes unrelated to cell cycle. In this review, we will summarize our current understanding of APC(Cdh1) function in cell cycle and beyond.

引用

页数：7

共 91 条

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