Cell fate transitions and the replication timing decision point

被引：30

作者：

Gilbert, David M. ^{[1
]}

机构：

[1] Florida State Univ, Dept Biol Sci, Tallahassee, FL 32306 USA

来源：

JOURNAL OF CELL BIOLOGY | 2010年 / 191卷 / 05期

关键词：

EMBRYONIC STEM-CELLS; GENE-REGULATION; DNA-REPLICATION; NUCLEAR LAMINA; IN-VITRO; EARLY G1; CHROMATIN; GENOME; PHASE; DIFFERENTIATION;

D O I：

10.1083/jcb.201007125

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent findings suggest that large-scale remodeling of three dimensional (3D) chromatin architecture occurs during a brief period in early G1 phase termed the replication timing decision point (TDP). In this speculative article, I suggest that the TDP may represent an as yet unappreciated window of opportunity for extracellular cues to influence 3D architecture during stem cell fate decisions. I also describe several testable predictions of this hypothesis.

引用

页码：899 / 903

页数：5

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