Fetal gene reactivation

被引：45

作者：

Swank, RA ^{[1
]}

Stamatoyannopoulos, G ^{[1
]}

机构：

[1] Univ Washington, Div Med Genet, Seattle, WA 98195 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1998年 / 8卷 / 03期

关键词：

D O I：

10.1016/S0959-437X(98)80095-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Reactivation of silent fetal or embryonic genes could be used for the treatment of genetic diseases caused by mutations of genes normally expressed during the adult stage of development. A paradigm of this approach is the activation of fetal hemoglobin synthesis in adult individuals and its use in the treatment of beta chain hemoglobinopathies. The current understanding of the molecular control of the beta globin locus is reviewed, as are the cellular and molecular basis of induction of fetal hemoglobin in the adult and the approaches used for stimulation of fetal hemoglobin synthesis in patients with beta chain hemoglobinopathies.

引用

页码：366 / 370

页数：5

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