Chemical neurostimulation using pulse code modulation (PCM) microfluidic chips

被引：19

作者：

Azizi, Farouk ^{[1
]}

Lu, Hui ^{[2
]}

Chiel, Hillel J. ^{[2
,3
,4
]}

Mastrangelo, Carlos H. ^{[5
,6
]}

机构：

[1] Purdue Univ Calumet, Dept Elect & Comp Engn, Hammond, IN 46323 USA

[2] Case Western Reserve Univ, Dept Biol, Cleveland, OH 44106 USA

[3] Case Western Reserve Univ, Dept Neurosci, Cleveland, OH 44106 USA

[4] Case Western Reserve Univ, Dept Biomed Engn, Cleveland, OH 44106 USA

[5] Univ Utah, Dept Elect & Comp Engn, Salt Lake City, UT 84112 USA

[6] Univ Utah, Dept Bioengn, Salt Lake City, UT 84112 USA

来源：

JOURNAL OF NEUROSCIENCE METHODS | 2010年 / 192卷 / 02期

关键词：

Aplysia californica; Neurostimulation; PDMS; Microfluidic; Pulse code modulation; DRUG-DELIVERY; MICROELECTRODES; STIMULATION; CHANNELS;

D O I：

10.1016/j.jneumeth.2010.07.011

中图分类号：

Q5 [生物化学];

学科分类号：

070307 [化学生物学];

摘要：

We report the implementation of a chemical neurostimulation technique using microfluidic devices. The microfluidic chip in this research is used for the in vitro study of the nervous system of Aplysia californica under localized chemical stimulation. The polydimethylsiloxane (PDMS) device is a one-bit pulse code modulator that digitally controls the concentration of the non-hydrolysable cholinergic agonist carbachol injected directly above a ganglion. The chip was successful in repeatedly and controllably inducing bursts of ingestive-like patterns. The ability of the chip to induce rhythmic activity through the sheath of the ganglion suggests that it could serve as the basis for an implantable, in vivo device to control neural activity and motor behavior using chemical stimulation. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：193 / 198

页数：6

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