Preparation of highly enantiopure β-amino esters by Candida antarctica lipase A

被引：72

作者：

Gedey, S

Liljeblad, A

Lázár, L

Fülöp, F

Kanerva, LT

机构：

[1] Univ Turku, Dept Chem, FIN-20520 Turku, Finland

[2] Univ Turku, Lab Synthet Drug Chem, FIN-20520 Turku, Finland

[3] Univ Szeged, Inst Pharmaceut Chem, H-6701 Szeged, Hungary

来源：

TETRAHEDRON-ASYMMETRY | 2001年 / 12卷 / 01期

关键词：

D O I：

10.1016/S0957-4166(01)00002-7

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The enantioselectivities for the reactions of aliphatic beta -substituted beta -amino esters [RCH(NH2)CH2CO2Et with R = Me, Et, n-Pr, i-Pr, CHEt2, cyclohexyl and Ph] with butyl butanoate in neat butyl butanoate and with 2,2,2-trifluoroethyl butanoate in diisopropyl ether were studied in the presence of Candida antarctica lipase A. Enantioselectivities ranging from good (E=70-100) to excellent (E>100) were commonly observed, allowing gram-scale resolution of the substrates. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：105 / 110

页数：6

共 23 条

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