Interfacing functionalized carbon nanohorns with primary phagocytic cells

被引：38

作者：

Lacotte, Stephanie ^{[2
]}

Garcia, Ainara ^{[1
]}

Decossas, Marion ^{[2
]}

Al-Jamal, Wafa' T. ^{[3
]}

Li, Shouping ^{[2
]}

Kostarelos, Kostas ^{[3
]}

Muller, Sylviane ^{[2
]}

Prato, Maurizio ^{[1
]}

Dumortier, Helene ^{[2
]}

Bianco, Alberto ^{[2
]}

机构：

[1] Univ Trieste, Dipartimento Sci Farmaceut, I-34127 Trieste, Italy

[2] CNRS, Inst Biol Mol & Cellulaire, UPR Immunol & Chim Therapeut 9021, F-67000 Strasbourg, France

[3] Univ London, Sch Pharm, Nanomed Lab, Ctr Drug Delivery Res, London WC1N 1AX, England

来源：

ADVANCED MATERIALS | 2008年 / 20卷 / 12期

关键词：

D O I：

10.1002/adma.200702753

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Functionalized carbon nanohorns (f-CNH) are uptaken by macrophages, without affecting cell viability. f-CNH induce the production of reactive oxygen species and of pro-inflammatory cytokines. The level of inflammation, although moderate, should be taken into consideration when using f-CNH for drug delivery. However, it could be exploited as an intrinsic f-CNH adjuvant function for biomedical applications requiring some activation of the immune system.

引用

页码：2421 / +

页数：7

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