DNA photodamage recognition by RNA polymerase II

被引：19

作者：

Brueckner, Florian

Cramer, Patrick

机构：

[1] Univ Munich, Dept Chem & Biochem, Gene Ctr Munich, D-81377 Munich, Germany

[2] Univ Munich, Dept Chem & Biochem, Ctr Integrated Protein Sci, D-81377 Munich, Germany

来源：

FEBS LETTERS | 2007年 / 581卷 / 15期

关键词：

transcription-coupled DNA repair; multisubunit cellular RNA polymerases; structural biology of gene transcription;

D O I：

10.1016/j.febslet.2007.05.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

During gene transcription, RNA polymerase (Pol) II encounters obstacles, including lesions in the DNA template. Here, we review a recent structure-function analysis of Pol II transcribing DNA with a bulky photo-lesion in the template strand. The study provided the molecular basis for recognition of a damaged DNA by Pol II, which is the first step in transcription-coupled DNA repair (TCR). The results have general implications for damage recognition and the TCR mechanism. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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页码：2757 / 2760

页数：4

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