New 5-(2-ethenylsubstituted)-3(2H)-furanones with in vitro antiproliferative activity

被引：56

作者：

Chimichi, S

Boccalini, M

Cosimelli, B

Dall'Acqua, F

Viola, G

机构：

[1] Dipartimento Chim Organ U Schiff, I-50019 Sesto Fno, Firenze, Italy

[2] Univ Naples Federico II, Dipartimento Chim Farmaceut & Tossicol, I-80131 Naples, Italy

[3] Dipartimento Sci Farmaceut, I-35131 Padua, Italy

来源：

TETRAHEDRON | 2003年 / 59卷 / 28期

关键词：

D O I：

10.1016/S0040-4020(03)00776-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient route to new 3(2H)-furanones is described through hydrogenolysis and subsequent acidic hydrolysis of isoxazoles. The antiproliferative activity of title compounds were evaluated against leukemia-, carcinoma-, neuroblastoma-, and sarcoma-derived human cell lines in comparison to the natural compound geiparvarin. The structure activity relationship indicated that the maximum in vitro antiproliferative activity correlates with the presence of a heterocyclic ring on the ethenyl moiety. (C) 2003 Elsevier Science Ltd. All rights reserved.

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页码：5215 / 5223

页数：9

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