A short synthesis of preussin: Use of allyldimethylsilyl as masked hydroxyl

被引:10
作者
Dikshit, DK [1 ]
Goswami, LN [1 ]
Singh, VS [1 ]
机构
[1] Cent Drug Res Inst, Div Med Chem, Lucknow 226001, Uttar Pradesh, India
关键词
natural product; antifungal agents; (3+2) annulation; allydimethylsilyl; pyrrolidine alkaloid;
D O I
10.1055/s-2003-41433
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A short and efficient synthesis of Preussin utilizing allyldimethylsilyl group as hydroxyl equivalent via an interesting (3+2) annulation reaction involving non-classical pentavalent silicon cation transition state, has been described.
引用
收藏
页码:1737 / 1739
页数:3
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