Flow and batch mode focused microwave synthesis of 5-amino-4-cyanopyrazoles and their further conversion to 4-aminopyrazolopyrimidines

被引：79

作者：

Smith, Catherine J. ^{[1
]}

Iglesias-Sigueenza, Francisco Javier ^{[1
]}

Baxendale, Ian R. ^{[1
]}

Ley, Steven V. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Innovat Technol Ctr ACS, Cambridge CB2 1EW, England

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2007年 / 5卷 / 17期

关键词：

D O I：

10.1039/b709043a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new approach to the synthesis of 5-amino-4-cyanopyrazoles has been developed, utilising a novel flow microwave device. These products are then converted by a batch mode microwave process to structurally more complex dimeric and 'mixed' pyrazolopyrimidine structures.

引用

页码：2758 / 2761

页数：4

共 42 条

[1] A simple continuous flow microwave reactor
Bagley, MC
Jenkins, RL
Lubinu, MC
Mason, C
Wood, R
[J]. JOURNAL OF ORGANIC CHEMISTRY, 2005, 70 (17) : 7003 - 7006
[2] Fully automated continuous flow synthesis of 4,5-disubstituted oxazoles
Baumann, Marcus
Baxendale, Ian R.
Ley, Steven V.
Smith, Christoper D.
Tranmer, Geoffrey K.
[J]. ORGANIC LETTERS, 2006, 8 (23) : 5231 - 5234
[3] A flow reactor process for the synthesis of peptides utilizing immobilized reagents, scavengers and catch and release protocols
Baxendale, Ian R.
Ley, Steven V.
Smith, Christopher D.
Tranmer, Geoffrey K.
[J]. CHEMICAL COMMUNICATIONS, 2006, (46) : 4835 - 4837
[4] Microwave-assisted Suzuki coupling reactions with an encapsulated palladium catalyst for batch and continuous-flow transformations
Baxendale, Ian R.
Griffiths-Jones, Charlotte M.
Ley, Steven V.
Tranmer, Geoffrey K.
[J]. CHEMISTRY-A EUROPEAN JOURNAL, 2006, 12 (16) : 4407 - 4416
[5] Baxendale IR, 2006, CHIM OGGI, V24, P41
[6] Preparation of the neolignan natural product grossamide by a continuous-flow process
Baxendale, IR
Griffiths-Jones, CM
Ley, SV
Tranmer, GK
[J]. SYNLETT, 2006, (03) : 427 - 430
[7] Formation of 4-aminopyrimidines via the trimerization of nitriles using focused microwave heating
Baxendale, IR
Ley, SV
[J]. JOURNAL OF COMBINATORIAL CHEMISTRY, 2005, 7 (03): : 483 - 489
[8] BAXENDALE IR, 2007, IN PRESS COMB CHEM H
[9] Multicomponent reactions to form heterocycles by microwave-assisted continuous flow organic synthesis
Bremner, W. Stacy
Organ, Michael G.
[J]. JOURNAL OF COMBINATORIAL CHEMISTRY, 2007, 9 (01): : 14 - 16
[10] POTENTIAL PURINE ANTAGONISTS .6. SYNTHESIS OF 1-ALKYL-4-SUBSTITUTED AND 1-ARYL-4-SUBSTITUTED PYRAZOLO[3,4-D]PYRIMIDINES
CHENG, CC
ROBINS, RK
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1956, 21 (11) : 1240 - 1256

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