Seasonal affective disorder and serotonin-related polymorphisms

被引:34
作者
Johansson, C [1 ]
Smedh, C
Partonen, T
Pekkarinen, P
Paunio, T
Ekholm, J
Peltonen, L
Lichtermann, D
Palmgren, J
Adolfsson, R
Schalling, M
机构
[1] Karolinska Inst, Dept Mol Med, Neurogenet Unit, Karolinska Hosp, S-17176 Stockholm, Sweden
[2] Umea Univ, Div Psychiat, Dept Clin Sci, S-90185 Umea, Sweden
[3] Natl Publ Hlth Inst, Dept Mental Hlth & Alcohol Res, FIN-00300 Helsinki, Finland
[4] Natl Publ Hlth Inst, Dept Human Mol Genet, FIN-00300 Helsinki, Finland
[5] Univ Helsinki, Dept Med Genet, FIN-00014 Helsinki, Finland
[6] Univ Bonn, Dept Psychiat, D-53105 Bonn, Germany
[7] Stockholm Univ, Dept Math Stat, S-10691 Stockholm, Sweden
[8] Karolinska Inst, Dept Med Epidemiol, S-17177 Stockholm, Sweden
关键词
depression; seasonality; serotonin transporter; serotonin receptor 2A; serotonin receptor 2C; tryptophan hydroxylase; white; association study;
D O I
10.1006/nbdi.2000.0373
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Disturbances in central serotonergic systems have been hypothesized to be involved in seasonal affective disorder (SAD). Association between SAD and the shorter allele of the serotonin transporter promoter repeat length polymorphism (5-HTTLPR) has been reported in an American sample. We have genotyped 82 SAD patients and 82 healthy controls from Sweden, Finland, and Germany for this and five other polymorphisms in the genes coding for serotonin receptors 5-HT2A and 5-HT2C, tryptophan hydroxylase and white. No associations with SAD or seasonality (seasonal variations in mood and behavior) were detected. Although minor effects cannot be excluded, our results suggest that these polymorphisms do not play a major role in the pathogenesis of SAD in the northern European population. (C) 2001 Academic Press.
引用
收藏
页码:351 / 357
页数:7
相关论文
共 39 条
[1]   Association of the serotonin transporter promoter regulatory region polymorphism and obsessive-compulsive disorder [J].
Bengel, D ;
Greenberg, BD ;
Corá-Locatelli, G ;
Altemus, M ;
Heils, A ;
Li, Q ;
Murphy, DL .
MOLECULAR PSYCHIATRY, 1999, 4 (05) :463-466
[2]   Polymorphic imprinting of the serotonin-2A (5-HT2A) receptor gene in human adult brain [J].
Bunzel, R ;
Blümcke, I ;
Cichon, S ;
Normann, S ;
Schramm, J ;
Propping, P ;
Nöthen, MM .
MOLECULAR BRAIN RESEARCH, 1998, 59 (01) :90-92
[3]   SEASONAL AND CIRCADIAN MONOAMINE VARIATIONS IN HUMAN BRAINS EXAMINED POSTMORTEM [J].
CARLSSON, A ;
SVENNERHOLM, L ;
WINBLAD, B .
ACTA PSYCHIATRICA SCANDINAVICA, 1980, 61 :75-85
[4]  
Collier DA, 1996, MOL PSYCHIATR, V1, P453
[5]   Association between 5-HT2A gene promoter polymorphism and anorexia nervosa [J].
Collier, DA ;
Arranz, MJ ;
Li, T ;
Mupita, D ;
Brown, N ;
Treasure, J .
LANCET, 1997, 350 (9075) :412-412
[6]   Association between seasonal affective disorder and the 5-HT2A promoter polymorphism, -1438G/A [J].
Enoch, MA ;
Goldman, D ;
Barnett, R ;
Sher, L ;
Mazzanti, CM ;
Rosenthal, NE .
MOLECULAR PSYCHIATRY, 1999, 4 (01) :89-92
[7]   Sex steroid control of mood, mental state and memory [J].
Fink, G ;
Sumner, BEH ;
McQueen, JK ;
Wilson, H ;
Rosie, R .
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 1998, 25 (10) :764-775
[8]   Neuroticism is not associated with the serotonin transporter (5-HTTLPR) polymorphism [J].
Flory, JD ;
Manuck, SB ;
Ferrell, RE ;
Dent, KM ;
Peters, DG ;
Muldoon, MF .
MOLECULAR PSYCHIATRY, 1999, 4 (01) :93-96
[9]   Gender differences in the heritability of seasonal mood change [J].
Jang, KL ;
Lam, RW ;
Livesley, WJ ;
Vernon, PA .
PSYCHIATRY RESEARCH, 1997, 70 (03) :145-154
[10]   An association study of a functional polymorphism of the serotonin transporter gene with personality and psychiatric symptoms [J].
Jorm, AF ;
Henderson, AS ;
Jacomb, PA ;
Christensen, H ;
Korten, AE ;
Rodgers, B ;
Tan, X ;
Easteal, S .
MOLECULAR PSYCHIATRY, 1998, 3 (05) :449-451