Polymorphic imprinting of the serotonin-2A (5-HT2A) receptor gene in human adult brain

被引：89

作者：

Bunzel, R

Blümcke, I

Cichon, S

Normann, S

Schramm, J

Propping, P

Nöthen, MM

机构：

[1] Univ Bonn, Inst Human Genet, D-53111 Bonn, Germany

[2] Univ Bonn, Med Ctr, Dept Neuropathol, D-53105 Bonn, Germany

[3] Univ Bonn, Med Ctr, Dept Neurosurg, D-53105 Bonn, Germany

来源：

MOLECULAR BRAIN RESEARCH | 1998年 / 59卷 / 01期

关键词：

genomic imprinting; HTR2A gene; monoallelic expression; neurobehavioral disorder; pharmacogenetic;

D O I：

10.1016/S0169-328X(98)00146-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have examined the imprinting status of the serotonin-2A (5-HT2A) receptor gene (HTR2A) in a series of 41 tissue samples from human adult brain. Using a Hpa Pi RFLP polymorphism in the coding region, we obtained evidence of monoallelic expression of HTR2A in 4 out of 18 informative individuals. However, biallelic expression of HTR2A was observed in other individuals (14/18), suggesting that within the human population HTR2A imprinting in brain is polymorphic. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：90 / 92

页数：3

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