A Stille biaryl-coupling approach to dityrosines. Formal total synthesis of Hazimycin

被引：5

作者：

Achab, S ^{[1
]}

Velay, L ^{[1
]}

机构：

[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 15期

关键词：

dityrosines; Stille cross-coupling; Hazimycin; stannyl tyrosines;

D O I：

10.1016/j.tetlet.2005.02.078

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Stille cross-coupling reaction between 3-tributylstannyltyrosine derivatives (15-23, 40), and 3-iodotyrosines (6-14, 39) afforded the corresponding dityrosines (24-37, 41). Additionally, this method provided a short and improved access to Hazimycin (3) a naturally occurring anti-fungal agent. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：2627 / 2630

页数：4

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