Recent advances in the synthesis of confortnationally locked nucleosides and their success in probing the critical question of conformational preferences by their biological targets

被引：33

作者：

Choi, Y ^{[1
]}

Moon, HR ^{[1
]}

Yoshimura, V ^{[1
]}

Marquez, VE ^{[1
]}

机构：

[1] NCI, Med Chem Lab, Ctr Canc Res, NIH,HHS, Frederick, MD 21702 USA

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2003年 / 22卷 / 5-8期

关键词：

bicyclo[3.1.0]hexane and bicyclo[3.1.0]hexene; conformationally locked carbocyclic nucleosides; pseudorotational analysis; D4T and carbovir analogues; intramolecular cyclopropanation; lipase-catalyzed resolution;

D O I：

10.1081/NCN-120021954

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The present work describes some recent approaches to the syntheses of three classes of locked-North nucleosides: beta-D-ribo-, beta-D-deoxyribo-, and beta-D-dideoxy-ribonucleosides. The method developed for the latter class permitted access to a novel bicyclo[3.1.0]hexene-type nucleosides structurally similar to D4T and carbovir. A structural analysis and biological activities are discussed.

引用

页码：547 / 557

页数：11

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