Conjugated Polymer Nanoparticles for Drug Delivery and Imaging

被引：241

作者：

Feng, Xuli ^{[1
]}

Lv, Fengting ^{[1
]}

Liu, Libing ^{[1
]}

Tang, Hongwei ^{[1
]}

Xing, Chengfen ^{[1
]}

Yang, Qiong ^{[1
]}

Wang, Shu ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Chem, Key Lab Organ Solids, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China

来源：

ACS APPLIED MATERIALS & INTERFACES | 2010年 / 2卷 / 08期

基金：

中国国家自然科学基金;

关键词：

conjugated polymers; nanoparticles; imaging; drug delivery; QUANTUM-DOT; POLY(L-GLUTAMIC ACID); ANTITUMOR-ACTIVITY; POLYELECTROLYTES; DNA; THERAPEUTICS; DOXORUBICIN; PLATFORMS; PARTICLES; SENSORS;

D O I：

10.1021/am100435k

中图分类号：

TB3 [工程材料学];

学科分类号：

082905 [生物质能源与材料];

摘要：

We prepared a new conjugated polymer nanoparticle with the size of about 50 nm that is prepared by electrostatic assembly of cationic conjugated polymer PFO and anionic poly(L-glutamic acid) conjugated with anticancer drug doxorubicin (PFO/PG-Dox). The PFO exhibits good fluorescence quantum yield, photostability, and little cytotoxicity to meet the essential requests for cell imaging. In PFO/PG-Dox nanoparticles, the fluorescence of PFO is highly quenched by Dox by electron transfer mechanism, and thus the PFO is in the fluorescence "turn-off" state. After PFO/PG-Dox nanoparticles are exposed to carboxypeptidase or are taken up by cancer cells, the poly(L-glutamic acid) is hydrolysed to release the Dox, inducing the activation of PFO fluorescence to "turn-on" state. This multifunctional nanoparticle system can deliver Dox to targeted cancer cells and monitor the Dox release based on fluorescence "turn-on" signal of PFO, which concurrently images the cancer cells. The present work opens the door for new functional studies of conjugated polymer in simultaneous imaging and disease therapeutics.

引用

页码：2429 / 2435

页数：7

共 68 条

[1]

Fluorescence superquenching of conjugated polyelectrolytes: applications for biosensing and drug discovery [J].