Collagen minipellet as a controlled release delivery system for tetanus and diphtheria toxoid

被引：30

作者：

Higaki, M

Azechi, Y

Takase, T

Igarashi, R

Nagahara, S

Sano, A

Fujioka, K

Nakagawa, N

Aizawa, C

Mizushima, Y

机构：

[1] St Marianna Univ, Inst Med Sci, Miyamae Ku, Kawasaki, Kanagawa 216, Japan

[2] Sumitomo Pharmaceut Co Ltd, Res Ctr, Formulat Res Labs, Ibaraki, Osaka 567, Japan

[3] Kitazato Inst, Biol Res Ctr, Kitamoto, Saitama 354, Japan

来源：

VACCINE | 2001年 / 19卷 / 23-24期

关键词：

collagen minipellet; vaccine; tetanus and diphtheria toxoid;

D O I：

10.1016/S0264-410X(01)00039-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The use of biodegradable polymer matrices as a single-dose vaccine delivery system was investigated using tetanus toroid (TT) and diphtheria toroid (DT). BALB/c mice were immunized with TT or DT in different formulations including individual, in minipellet and aluminum hydroxide (alum), and the antibody responses were monitored for 48 weeks. Antigens entrapped in minipellet elicited higher antibody responses compared to those obtained with individual antigens and antigens adsorbed to alum and the antibody levels remained elevated over 48 weeks. In addition, minipellet formulations induced the same subclasses of antibodies induced by alum formulations. These results raise the possibility to obtain optimal and long-lasting immune responses by a single administration of minipellet formulations. (C) 2001 Published by Elsevier Science Ltd.

引用

收藏

页码：3091 / 3096

页数：6

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