A novel dinuclear chiral niobium complex for Lewis acid catalyzed enantioselective reactions: Design of a tridentate ligand and elucidation of the catalyst structure

被引：42

作者：

Kobayashi, S ^{[1
]}

Arai, K ^{[1
]}

Shimizu, H ^{[1
]}

Ihori, Y ^{[1
]}

Ishitani, H ^{[1
]}

Yamashita, Y ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 05期

关键词：

asymmetric catalysis; chirality; Lewis acids; Mannich reaction; niobium;

D O I：

10.1002/anie.200462204

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two's company: By using a novel chiral ligand a dinuclear chiral niobium catalyst for highly enantioselective Mannich-type reactions was developed. Tridentate binol derivatives provide excellent asymmetric environments around the niobium atom, and the Mannich-type reactions proceeded smoothly in high yields with high enantioselectivities (see scheme; NMI = N-methylimidazole).

引用

页码：761 / 764

页数：4

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