Illuminating the landscape of host-pathogen interactions with the bacterium Listeria monocytogenes

被引:269
作者
Cossart, Pascale [1 ,2 ,3 ]
机构
[1] Inst Pasteur, Dept Biol Cellulaire & Infect, Unite Interact Bacteries Cellules, F-75015 Paris, France
[2] INSERM, U604, F-75015 Paris, France
[3] INRA USC2020, F-75015 Paris, France
基金
欧洲研究理事会;
关键词
bacterial invasion; mitochondria; posttranslational modifications; epigenetics; VIRULENCE REGULATOR PRFA; GENE-EXPRESSION; COMPARATIVE GENOMICS; HISTONE MODIFICATIONS; FLAGELLAR MOTILITY; BIOFILM FORMATION; IMMUNE-RESPONSES; INVASION PROTEIN; SURFACE PROTEIN; MODEL HOST;
D O I
10.1073/pnas.1112371108
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Listeria monocytogenes has, in 25 y, become a model in infection biology. Through the analysis of both its saprophytic life and infectious process, new concepts in microbiology, cell biology, and pathogenesis have been discovered. This review will update our knowledge on this intracellular pathogen and highlight the most recent breakthroughs. Promising areas of investigation such as the increasingly recognized relevance for the infectious process, of RNA-mediated regulations in the bacterium, and the role of bacterially controlled posttranslational and epigenetic modifications in the host will also be discussed.
引用
收藏
页码:19484 / 19491
页数:8
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