Epithelial stem cells, wound healing and cancer

被引：343

作者：

Arwert, Esther N. ^{[1
]}

Hoste, Esther ^{[1
]}

Watt, Fiona M. ^{[1
]}

机构：

[1] Li Ka Shing Ctr, Canc Res UK, Cambridge Res Inst, Cambridge CB2 ORE, England

来源：

NATURE REVIEWS CANCER | 2012年 / 12卷 / 03期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

GROWTH-FACTOR-ALPHA; GROUP BOX 1; HAIR FOLLICLE; BETA-CATENIN; TGF-BETA; BONE-MARROW; TRANSGENIC MICE; IN-VIVO; SONIC-HEDGEHOG; SKIN TUMOR;

D O I：

10.1038/nrc3217

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

It is well established that tissue repair depends on stem cells and that chronic wounds predispose to tumour formation. However, the association between stem cells, wound healing and cancer is poorly understood. Lineage tracing has now shown how stem cells are mobilized to repair skin wounds and how they contribute to skin tumour development. The signalling pathways, including WNT and Hedgehog, that control stem cell behaviour during wound healing are also implicated in tumour formation. Furthermore, tumorigenesis and wound repair both depend on communication between epithelial cells, mesenchymal cells and bone marrow-derived cells. These studies suggest ways to harness stem cells for wound repair while minimizing cancer risk.

引用

页码：170 / 180

页数：11

共 150 条

[51] Hallmarks of Cancer: The Next Generation [J].

Hanahan, Douglas ;

Weinberg, Robert A. .

CELL, 2011, 144 (05) :646-674

[52] Inflammation, DNA methylation and colitis-associated cancer [J].

Hartnett, Lori ;

Egan, Laurence J. .

CARCINOGENESIS, 2012, 33 (04) :723-731

[53] BASIC FIBROBLAST GROWTH-FACTOR STIMULATION OF EPIDERMAL WOUND-HEALING IN PIGS [J].

HEBDA, PA ;

KLINGBEIL, CK ;

ABRAHAM, JA ;

FIDDES, JC .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1990, 95 (06) :626-631

[54] Expression of activated MEK1 in differentiating epidermal cells is sufficient to generate hyperproliferative and inflammatory skin lesions [J].

Hobbs, RM ;

Silva-Vargas, V ;

Groves, R ;

Watt, FM .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2004, 123 (03) :503-515

[55] TGF-β receptor I conditional knockout mice develop spontaneous squamous cell carcinoma [J].

Honjo, Yasuyuki ;

Bian, Yansong ;

Kawakami, Koji ;

Molinolo, Alfredo ;

Longenecker, Glenn ;

Boppana, Ramanamurthy ;

Larsson, Jonas ;

Karlsson, Stefan ;

Gutkind, J. Silvio ;

Puri, Raj K. ;

Kulkarni, Ashok B. .

CELL CYCLE, 2007, 6 (11) :1360-1366

[56] Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland [J].

Horsley, Valerie ;

O'Carroll, Donal ;

Tooze, Reuben ;

Ohinata, Yasuhide ;

Saitou, Mitinori ;

Obukhanych, Tetyana ;

Nussenzweig, Michel ;

Tarakhovsky, Alexander ;

Fuchs, Elaine .

CELL, 2006, 126 (03) :597-609

[57] Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy [J].

Huang, Qian ;

Li, Fang ;

Liu, Xinjian ;

Li, Wenrong ;

Shi, Wei ;

Liu, Fei-Fei ;

O'Sullivan, Brian ;

He, Zhimin ;

Peng, Yuanlin ;

Tan, Aik-Choon ;

Zhou, Ling ;

Shen, Jingping ;

Han, Gangwen ;

Wang, Xiao-Jing ;

Thorburn, Jackie ;

Thorburn, Andrew ;

Jimeno, Antonio ;

Raben, David ;

Bedford, Joel S. ;

Li, Chuan-Yuan .

NATURE MEDICINE, 2011, 17 (07) :860-U231

[58] TGFβ signalling: a complex web in cancer progression [J].

Ikushima, Hiroaki ;

Miyazono, Kohei .

NATURE REVIEWS CANCER, 2010, 10 (06) :415-424

[59] In vivo characterization of bone marrow-derived fibroblasts recruited into fibrotic lesions [J].

Ishii, GH ;

Sangai, T ;

Sugiyama, K ;

Ito, T ;

Hasebe, T ;

Endoh, Y ;

Magae, U ;

Ochiai, A .

STEM CELLS, 2005, 23 (05) :699-706

[60] Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis [J].

Ito, M ;

Liu, YP ;

Yang, ZX ;

Nguyen, J ;

Liang, F ;

Morris, RJ ;

Cotsarelis, G .

NATURE MEDICINE, 2005, 11 (12) :1351-1354

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