Carbon Nanotubes in the Biological Interphase: The Relevance of Noncovalence

被引：56

作者：

Lee, Yeonju ^{[1
]}

Geckeler, Kurt E. ^{[1
]}

机构：

[1] World Class Univ, Inst Med Syst Engn, Dept Mat Sci & Engn, Dept Nanobio Mat & Elect,GIST, Kwangju 500712, South Korea

来源：

ADVANCED MATERIALS | 2010年 / 22卷 / 36期

关键词：

IN-VITRO; DELIVERY; CYTOTOXICITY; VIVO; PURIFICATION; TRANSPORTERS; DOXORUBICIN; TOXICITY; FUNCTIONALIZATION; BIOCOMPATIBILITY;

D O I：

10.1002/adma.201000746

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

With the increasing interest in the biological applications of carbon nanotubes, their interactions in the biological interphase and their general cytotoxicity have become major issues. In spite of their salient properties, major hurdles still exist for their use in biological applications, due to their main characteristics, including their hydrophobic surfaces and tendency to aggregate, as well as their unknown interactions in the cellular interphase. In this Research News, these characteristics of carbon nanotubes, a model nanomaterial, are investigated. Thus, the cytotoxicity of carbon nanotubes, the influence of functionalization, as well as their interactions with different mammalian cell lines are studied. Moreover, suggestions for the improvement of their biocompatibility and the design of biocompatible carbon nanotube-based systems are provided.

引用

页码：4076 / 4083

页数：8

共 63 条

[1] Multiwalled carbon nanotube-doxorubicin supramolecular complexes for cancer therapeutics [J].

Ali-Boucetta, Hanene ;

Al-Jamal, Khuloud T. ;

McCarthy, David ;

Prato, Maurizio ;

Bianco, Alberto ;

Kostarelos, Kostas .

CHEMICAL COMMUNICATIONS, 2008, (04) :459-461

[2] The reliability and limits of the MTT reduction assay for carbon nanotubes-cell interaction [J].

Belyanskaya, Larisa ;

Manser, Plus ;

Spohn, Philipp ;

Bruinink, Arle ;

Wick, Peter .

CARBON, 2007, 45 (13) :2643-2648

[3]

BESTERMAN JM, 1983, BIOCHEM J, V210, P1

[4] Applications of carbon nanotubes in drug delivery [J].

Bianco, A ;

Kostarelos, K ;

Prato, M .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2005, 9 (06) :674-679

[5] An in vitro study of the potential of carbon nanotubes and nanofibres to induce inflammatory mediators and frustrated phagocytosis [J].

Brown, D. M. ;

Kinloch, I. A. ;

Bangert, U. ;

Windle, A. H. ;

Walter, D. M. ;

Walker, G. S. ;

Scotchford, C. A. ;

Donaldson, K. ;

Stone, V. .

CARBON, 2007, 45 (09) :1743-1756

[6] Size-dependent proinflammatory effects of ultrafine polystyrene particles: A role for surface area and oxidative stress in the enhanced activity of ultrafines [J].

Brown, DM ;

Wilson, MR ;

MacNee, W ;

Stone, V ;

Donaldson, K .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 2001, 175 (03) :191-199

[7] Nanomaterials and nanoparticles: Sources and toxicity [J].

Buzea, Cristina ;

Pacheco, Ivan I. ;

Robbie, Kevin .

BIOINTERPHASES, 2007, 2 (04) :MR17-MR71

[8] Purification and characterization of single-wall carbon nanotubes (SWNTs) obtained from the gas-phase decomposition of CO (HiPco process) [J].

Chiang, IW ;

Brinson, BE ;

Huang, AY ;

Willis, PA ;

Bronikowski, MJ ;

Margrave, JL ;

Smalley, RE ;

Hauge, RH .

JOURNAL OF PHYSICAL CHEMISTRY B, 2001, 105 (35) :8297-8301

[9] Amphiphilic helical peptide enhances the uptake of single-walled carbon nanotubes by living cells [J].

Chin, Shook-Fong ;

Baughman, Ray H. ;

Dalton, Alan B. ;

Dieckmann, Gregg R. ;

Draper, Rockford K. ;

Mikoryak, Carole ;

Musselman, Inga H. ;

Poenitzsch, Vasiliki Z. ;

Xie, Hui ;

Pantano, Paul .

EXPERIMENTAL BIOLOGY AND MEDICINE, 2007, 232 (09) :1236-1244

[10] Comparative genotoxicity of cobalt nanoparticles and ions on human peripheral leukocytes in vitro [J].

Colognato, R. ;

Bonelli, A. ;

Ponti, J. ;

Farina, M. ;

Bergamaschi, E. ;

Sabbioni, E. ;

Migliore, L. .

MUTAGENESIS, 2008, 23 (05) :377-382

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