Enantioselective trimethylsilylcyanation of aldehydes catalyzed by chiral lanthanoid alkoxides

被引：64

作者：

Qian, CT ^{[1
]}

Zhu, CJ ^{[1
]}

Huang, TS ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Organomet Chem Lab, Shanghai 200032, Peoples R China

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1998年 / 14期

关键词：

D O I：

10.1039/a802509f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first example of enantioselective trimethylsilylcyanation of aldehydes catalyzed by chiral binaphthol and binaphthol-modified lanthanum alkoxides has been achieved, in which an obvious effect of substituents at the 3,3'-positions of BINOL on the enantioselectivity was observed and 3,3'-bis(methoxyethyl)-BINOL had the advantage over simple BINOL to give (S)-products in excellent yields with 73% ee.

引用

页码：2131 / 2132

页数：2

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