Tyrosinase-like reactivity in a Cu2III(μ-O)2e species

被引：60

作者：

Company, Anna ^{[3
]}

Palavicini, Sara ^{[4
]}

Garcia-Bosch, Isaac ^{[3
]}

Mas-Balleste, Ruben ^{[1
,2
]}

Que, Lawrence, Jr. ^{[1
,2
]}

Rybak-Akimova, Elena V. ^{[5
]}

Casella, Luigi ^{[4
]}

Ribas, Xavi ^{[3
]}

Costas, Miquel ^{[3
]}

机构：

[1] Univ Minnesota, Ctr Metals Biocatalysis, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Dept Chem, Minneapolis, MN 55455 USA

[3] Univ Girona, Dept Quim, Girona 17071, Spain

[4] Univ Pavia, Dept Gen Chem, I-27100 Pavia, Italy

[5] Tufts Univ, Dept Chem, Medford, MA 02155 USA

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2008年 / 14卷 / 12期

关键词：

D O I：

10.1002/chem.200800229

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

A study was conducted to demonstrate a bis(μ-oxo)dicopper(III) species that binds and ortho-hydroxylates phenolates for reactivity of tyrosinase. The study characterized a metastable species from the low-temperature reaction of sodium p-chloro-phenolate (p-Cl-C6H4ONa) with a bis(μ-oxo)dicopper(III) species. The study found that the addition of 10 equivalents of the sodium salt of p-chlorophenol at -90°C can cause bleaching of the spectral features. High performance liquid chromatography (HPLC) analysis showed that 4-chlorocatechol was formed in 76% yield. The study used UV/UVis monitoring for reaction in acetone to determine the initial features to the bis(μ-oxo) species and found that these features disappear after phenolate addition. The study observed that the activation parameters for the monophenolase reaction catalyzed by tyrosinase.

引用

页码：3535 / 3538

页数：4

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