Shear-thinning hydrogels for biomedical applications

被引：719

作者：

Guvendiren, Murat ^{[1
]}

Lu, Hoang D. ^{[1
]}

Burdick, Jason A. ^{[1
]}

机构：

[1] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA

来源：

SOFT MATTER | 2012年 / 8卷 / 02期

基金：

美国国家科学基金会;

关键词：

ARTIFICIAL PROTEIN HYDROGELS; TISSUE ENGINEERING APPLICATIONS; BIODEGRADABLE COLLOIDAL GELS; HAIRPIN PEPTIDE HYDROGEL; CONTROLLED DRUG-DELIVERY; PEO TRIBLOCK COPOLYMERS; MESENCHYMAL STEM-CELLS; SITU-FORMING HYDROGELS; ALPHA-CYCLODEXTRIN; INCLUSION COMPLEXATION;

D O I：

10.1039/c1sm06513k

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Injectable hydrogels are becoming increasingly important in the fields of tissue engineering and drug delivery due to their tunable properties, controllable degradation, high water content, and the ability to deliver them in a minimally invasive manner. Shear-thinning is one promising technique for the application of injectable hydrogels, where preformed hydrogels can be injected by application of shear stress (during injection) and quickly self-heal after removal of shear. Importantly, these gels can be used to deliver biological molecules and cells during the injection process. This review aims to highlight the range of injectable shear-thinning hydrogel systems being developed, with a focus on the various mechanisms of formation and shear-thinning and their use in biomedical applications.

引用

页码：260 / 272

页数：13

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