Ergosterol peroxides as phospholipase A2 inhibitors from the fungus Lactarius hatsudake

被引：36

作者：

Gao, Jin-Ming

Wang, Min

Wei, Ge-Hong

Zhang, An-Ling

Draghici, Cristina

Konishi, Yasuo

机构：

[1] Natl Res Council Canada, Biotechnol Res Inst, Montreal, PQ H4P 2R2, Canada

[2] NW A&F Univ, Coll Sci, Nat Prod Resource Res Ctr, Yangling 712100, Shaanxi, Peoples R China

[3] Natl Engn Res Ctr Phytochem W China, Yangling 712100, Shaanxi, Peoples R China

来源：

PHYTOMEDICINE | 2007年 / 14卷 / 12期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

basidiomycetae; Lactarius hatsudake; ergosterol peroxides; phospholipase A(2); snake venoms; Crotalus adamenteus;

D O I：

10.1016/j.phymed.2006.12.006

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Four ergosterol derivatives (1-4), have been isolated for the first time from the fruiting bodies of a basidiomycete fungus, Lactarius hatsudake, through activity-guided fractionation. Their structures were determined, using spectroscopic analysis, as: (22E,24R)-ergosta-5,7,22-dien-3 beta-ol (ergosterol, 1); 5 alpha,8 alpha-epidioxy-(22E,24R)-ergosta-6,22-dien-3 beta-ol (ergosterol peroxide, 2); 5 alpha,8 alpha-epidioxy-(24S)-ergosta-6-en-3 beta-ol (3); and (22E,24R)-ergosta-7,22-dien-3 beta,5 alpha,6 beta-triol (cerevisterol, 4). Compounds 2 and 3 showed selective inhibitory activity against Crotalus adamenteus venom phospholipase A(2) (PLA(2)) enzyme, but not against Apis mellifcra bee venom PLA(2). The antiphospholipase A(2) activity of compounds 2 and 3 are reported here for the first time. (c) 2006 Elsevier GmbH. All rights reserved.

引用

页码：821 / 824

页数：4

共 15 条

[1]

Two fungal lanostane derivatives as phospholipase A(2) inhibitors [J].