Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion

被引：136

作者：

Nygren, Jens M. ^{[1
,2
,3
]}

Liuba, Karina ^{[1
,2
]}

Breitbach, Martin ^{[4
]}

Stott, Simon ^{[2
,5
]}

Thoren, Lina ^{[1
,2
]}

Roell, Wilhelm ^{[6
]}

Geisen, Caroline ^{[4
]}

Sasse, Philipp ^{[4
]}

Kirik, Deniz ^{[2
,5
]}

Bjorklund, Anders ^{[2
,5
]}

Nerlov, Claus ^{[2
,7
]}

Fleischmann, Bernd K. ^{[4
]}

Jovinge, Stefan ^{[1
,2
,8
]}

Jacobsen, Sten Eirik W. ^{[1
,2
,9
]}

机构：

[1] Lund Univ, Hematopoiet Stem Cell Lab, S-22184 Lund, Sweden

[2] Lund Univ, Lund Strateg Res Ctr Stem Cell Biol & Cell Therap, S-22184 Lund, Sweden

[3] Lund Univ, Div Immunol, Dept Expt Med Sci, S-22184 Lund, Sweden

[4] Univ Bonn, Life & Brain Ctr, Inst Physiol 1, D-53105 Bonn, Germany

[5] Lund Univ, Wallenberg Neurosci Ctr, Div Neurobiol, S-22362 Lund, Sweden

[6] Univ Bonn, Dept Cardiac Surg, D-53105 Bonn, Germany

[7] EMBL Monterotondo, Mouse Biol Unit, I-00016 Monterotondo, Italy

[8] Lund Univ, Univ Lund Hosp, Dept Cardiol, Coronary Program,Heart & Lung Div, S-22185 Lund, Sweden

[9] Univ Oxford, John Radcliffe Hosp, Haematopoiet Stem Cell Lab, Weatherall Inst Mol Med, Headington OX3 9DS, England

来源：

NATURE CELL BIOLOGY | 2008年 / 10卷 / 05期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/ncb1721

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 [细胞生物学]; 090102 [作物遗传育种];

摘要：

Recent studies have suggested that regeneration of non-haematopoietic cell lineages can occur through heterotypic cell fusion(1-3) with haematopoietic cells of the myeloid lineage(2 - 6). Here we show that lymphocytes also form heterotypic-fusion hybrids with cardiomyocytes, skeletal muscle, hepatocytes and Purkinje neurons. However, through lineage fate-mapping we demonstrate that such in vivo fusion of lymphoid and myeloid blood cells does not occur to an appreciable extent in steady-state adult tissues or during normal development. Rather, fusion of blood cells with different non-haematopoietic cell types is induced by organ-specific injuries or whole-body irradiation(1-10), which has been used in previous studies to condition recipients of bone marrow transplants. Our findings demonstrate that blood cells of the lymphoid and myeloid lineages contribute to various non-haematopoietic tissues by forming rare fusion hybrids, but almost exclusively in response to injuries or inflammation.

引用

页码：584 / 592

页数：9

共 30 条

[1]

Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes [J].