Short-term canine implantation of a glucose monitoring-telemetry device

被引:10
作者
Atanasov, P [1 ]
Yang, S [1 ]
Salehi, C [1 ]
Ghindilis, AL [1 ]
Wilkins, E [1 ]
机构
[1] UNIV NEW MEXICO, SCH ENGN, DEPT CHEM & NUCL ENGN, ALBUQUERQUE, NM 87131 USA
基金
美国国家科学基金会;
关键词
glucose biosensor; telemetry; in vivo glucose monitoring;
D O I
10.1016/S1350-4533(96)00024-0
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
In this study we report the development and short-term in vivo evaluation of an integrated implantable device consisting of an amperometric glucose biosensor, a miniature potentiostat, a FM signal transmitter, and power supply. The device (dimensions: 5.0 x 7.0 x 1.5 cm) was implanted under the skin of medium-size anaesthetized dog. The experimental set-up included several methods for data collection: analog recording via wired X-T chart recorders; data collection by wearable microprocessor-data logger, and remote data collection via antenna and receiver linked to a computer-based data acquisition system. The device (sensor) performance was evaluated in vitro prior to implantation, using different model solutions simulating the physiological environment. A linear response to glucose concentration was obtained up to 25 mM glucose, with a sensitivity of 0.5 mu A/mM. The results of short-term subcutaneous implantation of the integrated device reveal adequate monitoring of an artificially-induced glycaemia. The delay-time was 3-7 minutes. These tests demonstrate the feasibility of data transmission to the telemetry system through the skin of a medium-sized dog and allow the commencement of chronic in vivo experimentation. Copyright (C) 1996 Elsevier Science Ltd for IPEMB.
引用
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页码:632 / 640
页数:9
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