Chromatin remodeling and cancer, part I: covalent histone modifications

被引:284
作者
Wang, Gang G.
Allis, C. David
Chi, Ping
机构
[1] Rockefeller Univ, Lab Chromatin Biol, New York, NY 10021 USA
[2] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10021 USA
关键词
D O I
10.1016/j.molmed.2007.07.003
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Dynamic chromatin remodeling underlies many, if not all, DNA-templated biological processes, including gene transcription; DNA replication and repair; chromosome condensation; and segregation and apoptosis. Disruption of these processes has been linked to the development and progression of cancer. The mechanisms of dynamic chromatin remodeling include the use of covalent histone modifications, histone variants, ATP-dependent complexes and DNA methylation. Together, these mechanisms impart variation into the chromatin fiber, and this variation gives rise to an 'epigenetic landscape' that extends the biological output of DNA alone. Here, we review recent advances in chromatin remodeling, and pay particular attention to mechanisms that appear to be linked to human cancer. Where possible, we discuss the implications of these advances for disease management strategies.
引用
收藏
页码:363 / 372
页数:10
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共 77 条
[21]   Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer [J].
Fraga, MF ;
Ballestar, E ;
Villar-Garea, A ;
Boix-Chornet, M ;
Espada, J ;
Schotta, G ;
Bonaldi, T ;
Haydon, C ;
Ropero, S ;
Petrie, K ;
Iyer, NG ;
Pérez-Rosado, A ;
Calvo, E ;
Lopez, JA ;
Cano, A ;
Calasanz, MJ ;
Colomer, D ;
Piris, MA ;
Ahn, N ;
Imhof, A ;
Caldas, C ;
Jenuwein, T ;
Esteller, M .
NATURE GENETICS, 2005, 37 (04) :391-400
[22]   Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases [J].
García-Cao, M ;
O'Sullivan, R ;
Peters, AHFM ;
Jenuwein, T ;
Blasco, MA .
NATURE GENETICS, 2004, 36 (01) :94-99
[23]   The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis [J].
Garkavtsev, I ;
Kozin, SV ;
Chernova, O ;
Xu, L ;
Winkler, F ;
Brown, E ;
Barnett, GH ;
Jain, RK .
NATURE, 2004, 428 (6980) :328-332
[24]   Histone modifying and chromatin remodelling enzymes in cancer and dysplastic syndromes [J].
Gibbons, RJ .
HUMAN MOLECULAR GENETICS, 2005, 14 :R85-R92
[25]   Epigenetics: A landscape takes shape [J].
Goldberg, Aaron D. ;
Allis, C. David ;
Bernstein, Emily .
CELL, 2007, 128 (04) :635-638
[26]   Heterochromatin revisited [J].
Grewal, Shiv I. S. ;
Jia, Songtao .
NATURE REVIEWS GENETICS, 2007, 8 (01) :35-46
[27]   SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells [J].
Hamamoto, R ;
Furukawa, Y ;
Morita, M ;
Iimura, Y ;
Silva, FP ;
Li, MH ;
Yagyu, R ;
Nakamura, Y .
NATURE CELL BIOLOGY, 2004, 6 (08) :731-740
[28]   The hallmarks of cancer [J].
Hanahan, D ;
Weinberg, RA .
CELL, 2000, 100 (01) :57-70
[29]   NOVEL ZINC FINGER GENE IMPLICATED AS MYC COLLABORATOR BY RETROVIRALLY ACCELERATED LYMPHOMAGENESIS IN E-MU-MYC TRANSGENIC MICE [J].
HAUPT, Y ;
ALEXANDER, WS ;
BARRI, G ;
KLINKEN, SP ;
ADAMS, JM .
CELL, 1991, 65 (05) :753-763
[30]   MLL: a histone methyltransferase disrupted in leukemia [J].
Hess, JL .
TRENDS IN MOLECULAR MEDICINE, 2004, 10 (10) :500-507