IL-17-producing T cells in lupus nephritis

被引：95

作者：

Apostolidis, S. A. ^{[1
]}

Crispin, J. C. ^{[1
]}

Tsokos, G. C. ^{[1
]}

机构：

[1] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Div Rheumatol, Boston, MA 02215 USA

来源：

LUPUS | 2011年 / 20卷 / 02期

基金：

美国国家卫生研究院;

关键词：

lupus nephritis; IL-17; IL-23; double negative T cells; tissue damage; SYSTEMIC AUTOIMMUNITY; TISSUE INFLAMMATION; TGF-BETA; IL-17; ERYTHEMATOSUS; CHEMOKINE; EXPRESSION; IL-23; STAT3; TH17;

D O I：

10.1177/0961203310389100

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Significant evidence implicates interleukin-17 (IL-17) in the pathogenesis of systemic lupus erythematosus (SLE), particularly in the development of tissue damage. IL-17 production and IL-17-producing CD4+ and CD3+ CD4-CD8- cells are increased in patients with SLE. IL-17-producing cells are present in the inflamed kidney tissues from patients with lupus nephritis. In lupus-prone mice, IL-17 production appears to be involved in the expression of disease pathology and pharmacologic or genetic manipulation of its production results in suppression of the disease. It becomes obvious that the use of biologics including humanized anti-IL-17 antibodies or decoy IL-17 receptors deserve clinical consideration. Similarly, the development of drugs that suppress the production of IL-17 is in order. Lupus (2011) 20, 120-124.

引用

页码：120 / 124

页数：5

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