Magnetic Capsules for NMR Imaging: Effect of Magnetic Nanoparticles Spatial Distribution and Aggregation

被引：82

作者：

Abbasi, Azhar Zahoor ^{[2
]}

Gutierrez, Lucia ^{[3
]}

del Mercato, Loretta L. ^{[2
]}

Herranz, Fernando ^{[5
]}

Chubykalo-Fesenko, Oksana ^{[4
]}

Veintemillas-Verdaguer, Sabino ^{[3
]}

Parak, Wolfgang J. ^{[2
]}

Puerto Morales, M. ^{[3
]}

Gonzalez, Jesus M. ^{[1
]}

Hernando, Antonio ^{[1
,6
]}

de la Presa, Patricia ^{[1
,6
]}

机构：

[1] Inst Magnetismo Aplicado UCM ADIF CSIC, Madrid 28230, Spain

[2] Univ Marburg, Fachbereich Phys, D-35037 Marburg, Germany

[3] Inst Ciencia Mat Madrid CSIC, Dept Biomat & Mat Bioinspirados, Madrid 28049, Spain

[4] Inst Ciencia Mat Madrid CSIC, Dept Nanoestruct Superficies & Recubrimientos, Madrid 28049, Spain

[5] Ctr Invest Biomed Red Enfermedades Respiratories, Inst Estudios Biofunc, Madrid, Spain

[6] Univ Complutense Madrid, Dept Fis Mat, Madrid, Spain

来源：

JOURNAL OF PHYSICAL CHEMISTRY C | 2011年 / 115卷 / 14期

关键词：

IRON-OXIDE NANOPARTICLES; CONTRAST AGENTS; SIZE; PARTICLES; CANCER; MRI; POLYMER; SUSCEPTIBILITY; MICROCAPSULES; ENCAPSULATION;

D O I：

10.1021/jp1118234

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Magnetic and NMR relaxivity properties of gamma-Fe2O3 nanoparticles embedded into the walls of polyelectrolyte multilayer capsules and freely dispersed in a sodium borate buffer solution have been investigated. The different geometric distribution of both configurations provides the opportunity to study the relationship of water accessibility and magnetic properties of particles on the NMR relaxivity. Changes in their blocking temperature and average dipolar field were modeled as a function of packing fraction in the ensemble of free and entrapped nanoparticles. For free nanopartides with relatively low concentration, relaxivity values increase with packing fraction according to an increase in the dipolar field and larger water accessibility. However, for embedded nanoparticles in the capsule wall, packing fractions should be limited to optimize the efficiency of this system as magnetic resonance imaging (MRI) contrast agent.

引用

页码：6257 / 6264

页数：8

共 40 条

[1] Gd-loaded liposomes as T1, susceptibility, and CEST agents, all in one [J].

Aime, Silvio ;

Castelli, Daniela Delli ;

Lawson, Dale ;

Terreno, Enzo .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (09) :2430-+

[2]

ARSHADY R, 1999, MICROSPHERES MICROCA, V1

[3] Calcium-sensitive MRI contrast agents based on superparamagnetic iron oxide nanoparticles and calmodulin [J].

Atanasijevic, Tatjana ;

Shusteff, Maxim ;

Fam, Peter ;

Jasanoff, Alan .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (40) :14707-14712

[4] Finite-size effects in fine particles: magnetic and transport properties [J].

Batlle, X ;

Labarta, A .

JOURNAL OF PHYSICS D-APPLIED PHYSICS, 2002, 35 (06) :R15-R42

[5] On the mechanical stability of polymeric microcontainers functionalized with nanoparticles [J].

Bedard, Matthieu F. ;

Munoz-Javier, Almudena ;

Mueller, Renate ;

del Pino, Pablo ;

Fery, Andreas ;

Parak, Wolfgang J. ;

Skirtach, Andre G. ;

Sukhorukov, Gleb B. .

SOFT MATTER, 2009, 5 (01) :148-155

[6] Susceptibility of the disordered system of fine magnetic particles: a Langevin-dynamics study [J].

Berkov, DV ;

Gorn, NL .

JOURNAL OF PHYSICS-CONDENSED MATTER, 2001, 13 (41) :9369-9381

[7] Controlled Release from Bilayer-Decorated Magnetoliposomes via Electromagnetic Heating [J].

Chen, Yanjing ;

Bose, Arijit ;

Bothun, Geoffrey D. .

ACS NANO, 2010, 4 (06) :3215-3221

[8] Numerical evaluation of multidimensional energy barriers for FePt and Co particles [J].

Chubykalo, O. A. ;

Chantrell, R. W. .

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, 2004, 272 :E1169-E1171

[9] Multidimensional energy barrier distributions of interacting magnetic particles evaluated at different magnetization states [J].

Chubykalo-Fesenko, O ;

Chantrell, RW .

JOURNAL OF APPLIED PHYSICS, 2005, 97 (10)

[10] Gold Nanoparticles Generated in Ethosome Bilayers, As Revealed by Cryo-Electron-Tomography [J].

de la Presa, Patricia ;

Rueda, Tatiana ;

del Puerto Morales, Maria ;

Javier Chichon, F. ;

Arranz, Rocio ;

Maria Valpuesta, Jose ;

Hernando, Antonio .

JOURNAL OF PHYSICAL CHEMISTRY B, 2009, 113 (10) :3051-3057

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