Cortical dendritic activity correlates with spindle-rich oscillations during sleep in rodents

被引：101

作者：

Seibt, Julie ^{[1
,2
]}

Richard, Clement J. ^{[1
]}

Sigl-Gloeckner, Johanna ^{[3
]}

Takahashi, Naoya ^{[4
]}

Kaplan, David I. ^{[1
]}

Doron, Guy ^{[4
]}

de Limoges, Denis ^{[5
]}

Bocklisch, Christina ^{[4
]}

Larkum, Matthew E. ^{[4
]}

机构：

[1] Charite, NeuroCure Cluster Excellence, D-10117 Berlin, Germany

[2] Univ Surrey, Surrey Sleep Res Ctr, Guildford GU2 7XP, Surrey, England

[3] Humboldt Univ, Bernstein Ctr Computat Neurosci Berlin, D-10115 Berlin, Germany

[4] Humboldt Univ, Inst Biol, D-10117 Berlin, Germany

[5] Univ Bern, Dept Physiol, CH-3012 Bern, Switzerland

来源：

NATURE COMMUNICATIONS | 2017年 / 8卷

基金：

瑞士国家科学基金会;

关键词：

REM-SLEEP; PLASTICITY; EEG; CORTEX; INTEGRATION; RECORDINGS; TRANSITION; FREQUENCY; HUMANS; INPUT;

D O I：

10.1038/s41467-017-00735-w

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

How sleep influences brain plasticity is not known. In particular, why certain electro-encephalographic (EEG) rhythms are linked to memory consolidation is poorly understood. Calcium activity in dendrites is known to be necessary for structural plasticity changes, but this has never been carefully examined during sleep. Here, we report that calcium activity in populations of neocortical dendrites is increased and synchronised during oscillations in the spindle range in naturally sleeping rodents. Remarkably, the same relationship is not found in cell bodies of the same neurons and throughout the cortical column. Spindles during sleep have been suggested to be important for brain development and plasticity. Our results provide evidence for a physiological link of spindles in the cortex specific to dendrites, the main site of synaptic plasticity.

引用

页数：13

共 44 条

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