Screening in veterinary drug analysis and sports doping control based on full-scan, accurate-mass spectrometry

被引：76

作者：

Peters, R. J. B. ^{[1
]}

Stolker, A. A. M. ^{[1
]}

Mol, J. G. J. ^{[1
]}

Lommen, A. ^{[1
]}

Lyris, E. ^{[1
,2
]}

Angelis, Y. ^{[1
,2
]}

Vonaparti, A. ^{[1
,2
]}

Stamou, M. ^{[1
,2
]}

Georgakopoulos, C. ^{[1
,2
]}

Nielen, M. W. F. ^{[1
,3
]}

机构：

[1] Inst Food Safety, RIKILT, NL-6700 AE Wageningen, Netherlands

[2] Olymp Athlet Ctr Athens, Doping Control Lab Athens, Athens 15123, Greece

[3] Wageningen Univ, Organ Chem Lab, NL-6703 HB Wageningen, Netherlands

来源：

TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2010年 / 29卷 / 11期

关键词：

Chromatography; Food contaminant; Mass spectrometry (MS); Metabolite; Orbitrap; Prohibited substance; Sports doping; Time of flight (TOF); Unified screening; Veterinary drug; HORSE URINE ANALYSIS; GC-TOF MS; LIQUID-CHROMATOGRAPHY; GAS-CHROMATOGRAPHY; RESIDUE ANALYSIS; METABOLITE IDENTIFICATION; THRESHOLD SUBSTANCES; ORGANIC POLLUTANTS; UNKNOWN PESTICIDES; UPLC-TOF;

D O I：

10.1016/j.trac.2010.07.012

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A common trend in food contaminants and sports doping control is towards a limited number of targeted, full-scan, accurate-mass spectrometry (MS) methods based on time-of-flight (TOF) or Fourier-transform orbital trap (Orbitrap) mass analyzers. Retrospective analysis of the full-scan datasets of signals from emerging contaminants, novel metabolites and illegal designer substances is a major step forward. We present data from recent applications of gas chromatography with TOF-MS, ultra-high-performance liquid chromatography (LC) with TOE-MS and LC-Orbitrap MS in the screening of European Commission-regulated veterinary drugs and other contaminants in foods, and World Anti-Doping Agency-prohibited substances. We discuss the potential impact of these new approaches on future developments. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：1250 / 1268

页数：19

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