Maneuvering for advantage: the genetics of mouse susceptibility to virus infection

被引：9

作者：

Lee, SH

Dimock, K

Gray, DA

Beauchemin, N

Holmes, KV

Belouchi, M

Realson, J

Vidal, SM ^{[1
]}

机构：

[1] Univ Ottawa, Dept Biochem Microbiol & Immunol, Ottawa, ON K1H 8M5, Canada

[2] Ottawa Reg Canc Ctr, Ctr Canc Therapeut, Ottawa, ON K1H 1C4, Canada

[3] McGill Univ, Ctr Canc, Montreal, PQ H3G 1Y6, Canada

[4] McGill Univ, Dept Biochem, Montreal, PQ H3G 1Y6, Canada

[5] McGill Univ, Dept Med, Montreal, PQ H3G 1Y6, Canada

[6] McGill Univ, Dept Oncol, Montreal, PQ H3G 1Y6, Canada

[7] Univ Colorado, Dept Microbiol, Denver, CO 80262 USA

[8] Galileogenom Inc, Montreal, PQ H4T 2C7, Canada

来源：

TRENDS IN GENETICS | 2003年 / 19卷 / 08期

基金：

加拿大自然科学与工程研究理事会; 加拿大健康研究院;

关键词：

D O I：

10.1016/S0168-9525(03)00172-0

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Genetic studies of host susceptibility to infection contribute to our understanding of an organism's response to pathogens at the immunological, cellular, and molecular levels. In this review we describe how the study of host genetics in mouse models has helped our understanding of host defense mechanisms against viral infection, and how this knowledge can be extended to human infections. We focus especially on the innate mechanisms that function as the host's first line of defense against infection. We also discuss the main issues that confront this field, as well as its future.

引用

页码：447 / 457

页数：11