Maneuvering for advantage: the genetics of mouse susceptibility to virus infection

被引：9

作者：

Lee, SH

Dimock, K

Gray, DA

Beauchemin, N

Holmes, KV

Belouchi, M

Realson, J

Vidal, SM ^{[1
]}

机构：

[1] Univ Ottawa, Dept Biochem Microbiol & Immunol, Ottawa, ON K1H 8M5, Canada

[2] Ottawa Reg Canc Ctr, Ctr Canc Therapeut, Ottawa, ON K1H 1C4, Canada

[3] McGill Univ, Ctr Canc, Montreal, PQ H3G 1Y6, Canada

[4] McGill Univ, Dept Biochem, Montreal, PQ H3G 1Y6, Canada

[5] McGill Univ, Dept Med, Montreal, PQ H3G 1Y6, Canada

[6] McGill Univ, Dept Oncol, Montreal, PQ H3G 1Y6, Canada

[7] Univ Colorado, Dept Microbiol, Denver, CO 80262 USA

[8] Galileogenom Inc, Montreal, PQ H4T 2C7, Canada

来源：

TRENDS IN GENETICS | 2003年 / 19卷 / 08期

基金：

加拿大自然科学与工程研究理事会; 加拿大健康研究院;

关键词：

D O I：

10.1016/S0168-9525(03)00172-0

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Genetic studies of host susceptibility to infection contribute to our understanding of an organism's response to pathogens at the immunological, cellular, and molecular levels. In this review we describe how the study of host genetics in mouse models has helped our understanding of host defense mechanisms against viral infection, and how this knowledge can be extended to human infections. We focus especially on the innate mechanisms that function as the host's first line of defense against infection. We also discuss the main issues that confront this field, as well as its future.

引用

收藏

页码：447 / 457

页数：11

相关论文

共 91 条

[81] Crystal structure of murine sCEACAM1a[1,4]: a coronavirus receptor in the CEA family [J].

Tan, KM ;

Zelus, BD ;

Meijers, R ;

Liu, JH ;

Bergelson, JM ;

Duke, N ;

Zhang, R ;

Joachimiak, A ;

Holmes, KV ;

Wang, JH .

EMBO JOURNAL, 2002, 21 (09) :2076-2086

[82] Fv-4: Identification of the defect in Env and the mechanism of resistance to ecotropic murine leukemia virus [J].

Taylor, GM ;

Gao, Y ;

Sanders, DA .

JOURNAL OF VIROLOGY, 2001, 75 (22) :11244-11248

[83] Class II HLA alleles and hepatitis B virus persistence in African Americans [J].

Thio, CL ;

Carrington, M ;

Marti, D ;

O'Brien, SJ ;

Vlahov, D ;

Nelson, KE ;

Astemborski, J ;

Thomas, DL .

JOURNAL OF INFECTIOUS DISEASES, 1999, 179 (04) :1004-1006

[84] Mutation of gene for mannose-binding protein associated with chronic hepatitis B viral infection [J].

Thomas, HC ;

Foster, GR ;

Sumiya, M ;

McIntosh, D ;

Jack, DL ;

Turner, MW ;

Summerfield, JA .

LANCET, 1996, 348 (9039) :1417-1419

[85] Influence of MHC class II genotype on outcome of infection with hepatitis C virus [J].

Thursz, M ;

Yallop, R ;

Goldin, R ;

Trepo, C ;

Thomas, HC .

LANCET, 1999, 354 (9196) :2119-2124

[86] ASSOCIATION BETWEEN AN MHC CLASS-II ALLELE AND CLEARANCE OF HEPATITIS-B VIRUS IN THE GAMBIA [J].

THURSZ, MR ;

KWIATKOWSKI, D ;

ALLSOPP, CEM ;

GREENWOOD, BM ;

THOMAS, HC ;

HILL, AVS .

NEW ENGLAND JOURNAL OF MEDICINE, 1995, 332 (16) :1065-1069

[87] A conserved mechanism of retrovirus restriction in mammals [J].

Towers, G ;

Bock, M ;

Martin, S ;

Takeuchi, Y ;

Stoye, JP ;

Danos, O .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (22) :12295-12299

[88] Development and characterization of new flavivirus-resistant mouse strains bearing Flvr-like and Flvmr alleles from wild or wild-derived mice [J].

Urosevic, N ;

Silvia, OJ ;

Sangster, MY ;

Mansfield, JP ;

Hodgetts, SI ;

Shellam, GR .

JOURNAL OF GENERAL VIROLOGY, 1999, 80 :897-906

[89] Tmevpg1, a candidate gene for the control of Theiler's virus persistence, could be implicated in the regulation of gamma interferon [J].

Vigneau, S ;

Rohrlich, PS ;

Brahic, M ;

Bureau, JF .

JOURNAL OF VIROLOGY, 2003, 77 (10) :5632-5638

[90] The mosaic structure of variation in the laboratory mouse genome [J].

Wade, CM ;

Kulbokas, EJ ;

Kirby, AW ;

Zody, MC ;

Mullikin, JC ;

Lander, ES ;

Lindblad-Toh, K ;

Daly, MJ .

NATURE, 2002, 420 (6915) :574-578

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