Total synthesis of antigen Bacillus anthracis tetrasaccharide -: Creation of an anthrax vaccine candidate

被引：147

作者：

Werz, DB ^{[1
]}

Seeberger, PH ^{[1
]}

机构：

[1] ETH, Swiss Fed Inst Technol, Lab Organ Chem, CH-8093 Zurich, Switzerland

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 39期

关键词：

anthrose; carbohydrates; oligosaccharides; total synthesis; vaccines;

D O I：

10.1002/anie.200502615

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Fighting Anthrax by recognizing its coat: The spores of Bacillus anthracis bear unique oligosaccharides on their surface for interaction with a host. These specific oligosaccharides may prove useful in the development of vaccines against this major biowarfare threat. The total synthesis of such a vaccine candidate (see picture, Pent = 4-pentenyl) is reported. (Chemical Equation Presented) © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：6315 / 6318

页数：4

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