Direct C2-trifluoromethylation of indole derivatives catalyzed by copper acetate

被引：164

作者：

Shimizu, Ryo ^{[1
,2
]}

Egami, Hiromichi ^{[1
,3
]}

Nagi, Tatsuya ^{[1
]}

Chae, Jungha ^{[1
]}

Hamashima, Yoshitaka ^{[1
]}

Sodeoka, Mikiko ^{[1
,2
,3
]}

机构：

[1] RIKEN, ASI, Wako, Saitama 3510198, Japan

[2] Saitama Univ, Grad Sch Sci & Engn, Sakura Ku, Saitama 3388570, Japan

[3] JST, ERATO, Sodeoka Live Cell Chem Project, Wako, Saitama 3510198, Japan

来源：

TETRAHEDRON LETTERS | 2010年 / 51卷 / 45期

关键词：

Trifluoromethylation; Indole; Catalysis; Regioselective; MILD ELECTROPHILIC TRIFLUOROMETHYLATION; BEARING METHOXYCARBONYL; FLUORINE; CYCLIZATION; 2-(TRIFLUOROMETHYL)INDOLES; ANNULATION; REACTIVITY; REAGENT; ACCESS; ETHERS;

D O I：

10.1016/j.tetlet.2010.09.027

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Direct C2-selective trifluoromethylation of indole derivatives was achieved with Togni's hypervalent iodine reagent and CuOAc as a catalyst in MeOH under mild conditions, affording the desired C2-trifluoromethylated indoles in good yield (up to 90%). (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：5947 / 5949

页数：3

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