Acid-mediated formation of trifluoromethyl sulfonates from sulfonic acids and a hypervalent iodine trifluoromethylating agent

被引：79

作者：

Koller, Raffael ^{[1
]}

Huchet, Quentin ^{[1
]}

Battaglia, Philip ^{[1
]}

Welch, Jan M. ^{[1
]}

Togni, Antonio ^{[1
]}

机构：

[1] ETH, Swiss Fed Inst Technol, Dept Chem & Appl Biosci, CH-8093 Zurich, Switzerland

来源：

CHEMICAL COMMUNICATIONS | 2009年 / 40期

关键词：

ELECTROPHILIC TRIFLUOROMETHYLATION; REAGENT; TRIFLATE;

D O I：

10.1039/b913962a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A variety of sulfonic acids have been trifluoromethylated using 1-trifluoromethyl- 1,2-benziodoxol-3(1H)-one under mild conditions in good to excellent yields. Initial mechanistic investigations of this reaction show a clean second-order kinetics and only very weak substrate electronic effects.

引用

页码：5993 / 5995

页数：3

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