Therapeutic angiogenesis for brain ischemia: A brief review

被引：142

作者：

Fan, Yongfeng

Yang, Guo-Yuan

机构：

[1] Univ Calif San Francisco, Dept Anesthesia & Perioperat Care, San Francisco, CA 94110 USA

[2] Univ Calif San Francisco, Dept Neurol Surg, San Francisco, CA 94110 USA

来源：

JOURNAL OF NEUROIMMUNE PHARMACOLOGY | 2007年 / 2卷 / 03期

关键词：

angiogenesis; brain ischernia; blood vessel; endothelial progenitor cells;

D O I：

10.1007/s11481-007-9073-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

In the normal mature brain, blood vessel formation is tightly downregulated. However, pathologic processes such as ischemia can induce cerebral vascular regeneration. Angiogenesis is one of the major styles of new vessel formation. In this article, we summarize the major angiogenic factors in the brain, discuss the significant changes of angiogenic factors and endothelial progenitor cells (EPCs) in response to brain ischemia, and finally, review the therapeutic potential of angiogenic factors and EPCs in experimental cerebral ischemia based on the concept of neurovascular unit.

引用

收藏

页码：284 / 289

页数：6

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