Retrospective study of the safety of caspofungin in immunocompromised pediatric patients

被引:38
作者
Franklin, JA
McCormick, J
Flynn, PM
机构
[1] St Jude Childrens Res Hosp, Dept Infect Dis, Memphis, TN 38105 USA
[2] St Jude Childrens Res Hosp, Dept Pharmaceut, Memphis, TN 38105 USA
[3] Univ Tennessee, Hlth Sci Ctr, Dept Pediat, Knoxville, TN 37996 USA
关键词
caspofungin; pediatrics; antifungal; immunocompromised patients;
D O I
10.1097/01.inf.0000078164.80233.14
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Caspofungin is an antifungal medication proved efficacious and well-tolerated in adults. Twenty-five pediatric patients at St. Jude Children's Research Hospital who had received at least one dose of caspofungin were identified, and their records were reviewed retrospectively. Caspofungin was well-tolerated; only three patients experienced any adverse event judged possibly related to drug. Caspofungin appears to be safe in immunocompromised pediatric patients.
引用
收藏
页码:747 / 749
页数:3
相关论文
共 19 条
[11]   Zygomycosis in the 1990s in a tertiary-care cancer center [J].
Kontoyiannis, DP ;
Wessel, VC ;
Bodey, GP ;
Rolston, KVI .
CLINICAL INFECTIOUS DISEASES, 2000, 30 (06) :851-856
[12]   Epidemiology and outcome of mould infections in hematopoietic stem cell transplant recipients [J].
Marr, KA ;
Carter, RA ;
Crippa, F ;
Wald, A ;
Corey, L .
CLINICAL INFECTIOUS DISEASES, 2002, 34 (07) :909-917
[13]   Invasive fungal infections after allogeneic peripheral blood stem cell transplantation:: incidence and risk factors in 395 patients [J].
Martino, R ;
Subirá, M ;
Rovira, M ;
Solano, C ;
Vázquez, L ;
Sanz, GF ;
Urbano-Ispizua, A ;
Brunet, S ;
De la Cámara, R .
BRITISH JOURNAL OF HAEMATOLOGY, 2002, 116 (02) :475-482
[14]   NON-CANDIDA FUNGAL-INFECTIONS AFTER BONE-MARROW TRANSPLANTATION - RISK-FACTORS AND OUTCOME [J].
MORRISON, VA ;
HAAKE, RJ ;
WEISDORF, DJ .
AMERICAN JOURNAL OF MEDICINE, 1994, 96 (06) :497-503
[15]  
NISSEN DE, 2002, MOSBYS DRUG CONSULT
[16]   Discovery of novel antifungal (1,3)-β-D-glucan synthase inhibitors [J].
Onishi, J ;
Meinz, M ;
Thompson, J ;
Curotto, J ;
Dreikorn, S ;
Rosenbach, M ;
Douglas, C ;
Abruzzo, G ;
Flattery, A ;
Kong, L ;
Cabello, A ;
Vicente, F ;
Pelaez, F ;
Diez, MT ;
Martin, I ;
Bills, G ;
Giacobbe, R ;
Dombrowski, A ;
Schwartz, R ;
Morris, S ;
Harris, G ;
Tsipouras, A ;
Wilson, K ;
Kurtz, MB .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (02) :368-377
[17]   Dematiaceous fungi are an increasing cause of human disease [J].
Rossmann, SN ;
Cernoch, PL ;
Davis, JR .
CLINICAL INFECTIOUS DISEASES, 1996, 22 (01) :73-80
[18]   In vitro activity of a new pneumocandin antifungal, L-743,872, against azole-susceptible and -resistant Candida species [J].
Vazquez, JA ;
Lynch, M ;
Boikov, D ;
Sobel, JD .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (07) :1612-1614
[19]  
WALSH TJ, 2002, 42 INT C ANT AG CHEM