The development and regulation of gene repair

被引：54

作者：

Liu, L ^{[1
]}

Parekh-Olmedo, H ^{[1
]}

Kmiec, EB ^{[1
]}

机构：

[1] Univ Delaware, Dept Biol Sci, Newark, DE 19716 USA

来源：

NATURE REVIEWS GENETICS | 2003年 / 4卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrg1156

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

0A technique that can direct the repair of a genetic mutation in a human chromosome using the DNA repair machinery of the cell is under development. Although this approach is not as mature as other forms of gene therapy and fundamental problems continue to arise, it promises to be the ultimate therapy for many inherited disorders. There is a continuing effort to understand the potential and the limitations of this controversial approach.

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收藏

页码：679 / 689

页数：11

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