The renin-angiotensin system and natriuretic peptides in obesity-associated hypertension

被引：157

作者：

Engeli, S ^{[1
]}

Sharma, AM ^{[1
]}

机构：

[1] Univ Klinikum Humboldt, Charite, Franz Volhard Klin, Dept Hypertens & Nephrol, D-13122 Berlin, Germany

来源：

JOURNAL OF MOLECULAR MEDICINE-JMM | 2001年 / 79卷 / 01期

关键词：

adipose tissue; hypertension; obesity; atrial natriuretic peptide; renin-angiotensin system;

D O I：

10.1007/s001090000144

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Excessive accumulation of adipose tissue is associated with profound alterations in the cardiovascular system, including an increase in systemic blood pressure. It now appears clear that a central feature of obesity-associated hypertension is related to changes in sodium handling that may result from abnormalities in sym-pathetic nervous system activity, the renin-angiotensin-aldosterone system, natriuretic peptides, and kidney function. In this paper we review the role of these factors in the development of obesity-associated hypertension, thereby focusing on the potential role of adipose tissue in these alterations.

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收藏

页码：21 / 29

页数：9

相关论文

共 129 条

[1] Angiotensinogen, angiotensin II and adipose tissue development [J].

Ailhaud, G ;

Fukamizu, A ;

Massiera, F ;

Negrel, R ;

Saint-Marc, P ;

Teboul, M .

INTERNATIONAL JOURNAL OF OBESITY, 2000, 24 (Suppl 4) :S33-S35

[2] Pathophysiological role of leptin in obesity-related hypertension [J].

Aizawa-Abe, M ;

Ogawa, Y ;

Masuzaki, H ;

Ebihara, K ;

Satoh, N ;

Iwai, H ;

Matsuoka, N ;

Hayashi, T ;

Hosoda, K ;

Inoue, G ;

Yoshimasa, Y ;

Nakao, K .

JOURNAL OF CLINICAL INVESTIGATION, 2000, 105 (09) :1243-1252

[3] Annual deaths attributable to obesity in the United States [J].

Allison, DB ;

Fontaine, KR ;

Manson, JE ;

Stevens, J ;

VanItallie, TB .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 282 (16) :1530-1538

[4] Hypertension in obese Zucker rats - Role of angiotensin II and adrenergic activity [J].

AlonsoGalicia, M ;

Brands, MW ;

Zappe, DH ;

Hall, JE .

HYPERTENSION, 1996, 28 (06) :1047-1054

[5] Insulin down-regulates angiotensinogen gene expression and angiotensinogen secretion in cultured adipose cells [J].

Aubert, J ;

Safonova, I ;

Negrel, R ;

Ailhaud, G .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1998, 250 (01) :77-82

[6] Obesity is associated with tissue-specific activation of renal angiotensin-converting enzyme in vivo -: Evidence for a regulatory role of endothelin [J].

Barton, M ;

Carmona, R ;

Morawietz, HM ;

d'Uscio, LV ;

Goettsch, W ;

Hillen, H ;

Haudenschild, CC ;

Krieger, JE ;

Münter, K ;

Lattmann, T ;

Lüscher, TF ;

Shaw, S .

HYPERTENSION, 2000, 35 (01) :329-336

[7] THE SERUM ANGIOTENSINOGEN CONCENTRATION AND VARIANTS OF THE ANGIOTENSINOGEN GENE IN WHITE AND BLACK-CHILDREN [J].

BLOEM, LJ ;

MANATUNGA, AK ;

TEWKSBURY, DA ;

PRATT, JH .

JOURNAL OF CLINICAL INVESTIGATION, 1995, 95 (03) :948-953

[8] Tumor necrosis factor activates angiotensinogen gene expression by the Rel A transactivator [J].

Brasier, AR ;

Li, JY ;

Wimbish, KA .

HYPERTENSION, 1996, 27 (04) :1009-1017

[9] Body-mass index and mortality in a prospective cohort of US adults [J].

Calle, EE ;

Thun, MJ ;

Petrelli, JM ;

Rodriguez, C ;

Heath, CW .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 341 (15) :1097-1105

[10] Elevated sympathetic activity contributes to hypertension and salt sensitivity in diabetic obese Zucker rats [J].

Carlson, SH ;

Shelton, J ;

White, CR ;

Wyss, JM .

HYPERTENSION, 2000, 35 (01) :403-408

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