The renin-angiotensin system and natriuretic peptides in obesity-associated hypertension

被引：157

作者：

Engeli, S ^{[1
]}

Sharma, AM ^{[1
]}

机构：

[1] Univ Klinikum Humboldt, Charite, Franz Volhard Klin, Dept Hypertens & Nephrol, D-13122 Berlin, Germany

来源：

JOURNAL OF MOLECULAR MEDICINE-JMM | 2001年 / 79卷 / 01期

关键词：

adipose tissue; hypertension; obesity; atrial natriuretic peptide; renin-angiotensin system;

D O I：

10.1007/s001090000144

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Excessive accumulation of adipose tissue is associated with profound alterations in the cardiovascular system, including an increase in systemic blood pressure. It now appears clear that a central feature of obesity-associated hypertension is related to changes in sodium handling that may result from abnormalities in sym-pathetic nervous system activity, the renin-angiotensin-aldosterone system, natriuretic peptides, and kidney function. In this paper we review the role of these factors in the development of obesity-associated hypertension, thereby focusing on the potential role of adipose tissue in these alterations.

引用

收藏

页码：21 / 29

页数：9

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