The renin-angiotensin system and natriuretic peptides in obesity-associated hypertension

被引：157

作者：

Engeli, S ^{[1
]}

Sharma, AM ^{[1
]}

机构：

[1] Univ Klinikum Humboldt, Charite, Franz Volhard Klin, Dept Hypertens & Nephrol, D-13122 Berlin, Germany

来源：

JOURNAL OF MOLECULAR MEDICINE-JMM | 2001年 / 79卷 / 01期

关键词：

adipose tissue; hypertension; obesity; atrial natriuretic peptide; renin-angiotensin system;

D O I：

10.1007/s001090000144

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Excessive accumulation of adipose tissue is associated with profound alterations in the cardiovascular system, including an increase in systemic blood pressure. It now appears clear that a central feature of obesity-associated hypertension is related to changes in sodium handling that may result from abnormalities in sym-pathetic nervous system activity, the renin-angiotensin-aldosterone system, natriuretic peptides, and kidney function. In this paper we review the role of these factors in the development of obesity-associated hypertension, thereby focusing on the potential role of adipose tissue in these alterations.

引用

页码：21 / 29

页数：9

共 129 条

[41] Altered pressure-natriuresis in obese Zucker rats [J].

Fujiwara, K ;

Hayashi, K ;

Matsuda, H ;

Kubota, E ;

Honda, M ;

Ozawa, Y ;

Saruta, T .

HYPERTENSION, 1999, 33 (06) :1470-1475

[42]

Giacchetti G, 1999, INT J OBES RELAT S5, V23, pS71

[43] Visceral obesity and insulin resistance are associated with plasma aldosterone levels in women [J].

Goodfriend, TL ;

Kelley, DE ;

Goodpaster, BH ;

Winters, SJ .

OBESITY RESEARCH, 1999, 7 (04) :355-362

[44] Plasma aldosterone, plasma lipoproteins, obesity and insulin resistance in humans [J].

Goodfriend, TL ;

Egan, BM ;

Kelley, DE .

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 1999, 60 (5-6) :401-405

[45]

GRANGER JP, 1994, HYPERTENSION, V23, P8

[46] SYMPATHETIC ACTIVATION IN OBESE NORMOTENSIVE SUBJECTS [J].

GRASSI, G ;

SERAVALLE, G ;

CATTANEO, BM ;

BOLLA, GB ;

LANFRANCHI, A ;

COLOMBO, M ;

GIANNATTASIO, C ;

BRUNANI, A ;

CAVAGNINI, F ;

MANCIA, G .

HYPERTENSION, 1995, 25 (04) :560-563

[47] Body weight reduction, sympathetic nerve traffic, and arterial baroreflex in obese normotensive humans [J].

Grassi, G ;

Seravalle, G ;

Colombo, M ;

Bolla, G ;

Cattaneo, BM ;

Cavagnini, F ;

Mancia, G .

CIRCULATION, 1998, 97 (20) :2037-2042

[48] Dissociation between muscle and skin sympathetic nerve activity in essential hypertension, obesity, and congestive heart failure [J].

Grassi, G ;

Colombo, M ;

Seravalle, G ;

Spaziani, D ;

Mancia, G .

HYPERTENSION, 1998, 31 (01) :64-67

[49]

HAINAULT I, 1999, EAT WEIGHT DISORD-ST, V4, P31

[50] Abnormal kidney function as a cause and a consequence of obesity hypertension [J].

Hall, JE ;

Brands, MW ;

Henegar, JR ;

Shek, EW .

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 1998, 25 (01) :58-64

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