Long noncoding RNAs in cell biology

被引：328

作者：

Clark, Michael B. ^{[1
]}

Mattick, John S. ^{[1
]}

机构：

[1] Univ Queensland, Inst Mol Biosci, St Lucia, Qld 4072, Australia

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2011年 / 22卷 / 04期

基金：

澳大利亚研究理事会;

关键词：

Trafficking; Paraspeckles; Localization; Nucleus; Cytoplasm; Neurons; Development; NEURONAL BC1 RNA; GENOME-WIDE IDENTIFICATION; MEIOTIC REGULATOR MEI2P; REPEAT-CONTAINING RNA; MESSENGER-RNA; GENE-EXPRESSION; ANTISENSE RNA; X-CHROMOSOME; POLY(A)-BINDING PROTEIN; DENDRITIC LOCATION;

D O I：

10.1016/j.semcdb.2011.01.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Whole genome transcriptomic analyses have identified large numbers of dynamically expressed long non-protein-coding RNAs (lncRNAs) in mammals and other animals whose functions are, as yet, largely unknown. Here we summarize the growing evidence that lncRNAs, like mRNAs, can be trafficked to and function in a wide variety of subcellular locations. Investigation of the subcellular distribution of lncRNAs has the potential to greatly expand our knowledge not only of the function of lncRNAs but also of cell biology by identifying previously unknown subcellular structures and novel constituents of known cellular organelles. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：366 / 376

页数：11

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