Environmental health research in the post-genome era: New fields, new challenges, and new opportunities

被引：5

作者：

Bower, JJ

Shi, XL

机构：

[1] NIOSH, Pathol & Physiol Res Branch, Hlth Effects Lab Div, Morgantown, WV USA

[2] W Virginia Univ, Dept Basic Pharmaceut Sci, Morgantown, WV 26506 USA

来源：

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART B-CRITICAL REVIEWS | 2005年 / 8卷 / 02期

关键词：

D O I：

10.1080/10937400590909059

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 [工学]; 0830 [环境科学与工程];

摘要：

The human genome sequence provides researchers with a genetic framework to eventually understand the relationships of gene-environment interactions. This wealth of information has led to the birth of several related areas of research, including proteomics, functional genomics, pharmacogenomics, and toxicogenomics. Developing techniques such as DNA/protein microarrays, small-interfering RNA (siRNA) applications, two-dimensional gel electrophoresis, and mass spectrometry in conjunction with advanced analysis software and the availability of Internet databases offers a powerful set of tools to investigate an individual's response to specific stimuli. This review summarizes these emerging scientific fields and techniques focusing specifically on their applications to the complexities of gene-environment interactions and their potential role in environmental biosecurity.

引用

页码：71 / 94

页数：24

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