Postnatal neurodevelopmental disorders: Meeting at the synapse?

被引：494

作者：

Zoghbi, HY ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Neurol, Houston, TX 77030 USA

[3] Baylor Coll Med, Dept Mol & Human Genet, Div Neurosci, Houston, TX 77030 USA

[4] Baylor Coll Med, Howard Hughes Med Inst, Houston, TX 77030 USA

来源：

SCIENCE | 2003年 / 302卷 / 5646期

关键词：

D O I：

10.1126/science.1089071

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We often think of neurodevelopmental disorders as beginning before birth, and many certainly do. A handful, however, strike many months after birth, following a period of apparently normal growth and development. Autism and Rett syndrome are two such disorders, and here I consider some of their similarities at the phenotypic and pathogenic levels. I propose that both disorders result from disruption of postnatal or experience-dependent synaptic plasticity.

引用

页码：826 / 830

页数：5

共 84 条

[41] MeCP2 mutations in children with and without the phenotype of Rett syndrome
Hoffbuhr, K
Devaney, JM
LaFleur, B
Sirianni, N
Scacheri, C
Giron, J
Schuette, J
Innis, J
Marino, M
Philippart, M
Narayanan, V
Umansky, R
Kronn, D
Hoffman, EP
Naidu, S
[J]. NEUROLOGY, 2001, 56 (11) : 1486 - 1495
[42] A CASE OF AUTISM ASSOCIATED WITH PARTIAL TETRASOMY-15
HOTOPF, M
BOLTON, P
[J]. JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 1995, 25 (01) : 41 - 49
[43] Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism
Jamain, S
Quach, H
Betancur, C
Råstam, M
Colineaux, C
Gillberg, IC
Soderstrom, H
Giros, B
Leboyer, M
Gillberg, C
Bourgeron, T
Gillberg, C
Råstam, M
Gillberg, C
Nydén, A
Söderström, H
Leboyer, M
Betancur, C
Philippe, A
Giros, B
Colineaux, C
Cohen, D
Chabane, N
Mouren-Siméoni, MC
Brice, A
Sponheim, E
Spurkland, I
Skjeldal, OH
Coleman, M
Pearl, PL
Cohen, IL
Tsiouris, J
Zappella, M
Menchetti, G
Pompella, A
Aschauer, H
Van Maldergem, L
[J]. NATURE GENETICS, 2003, 34 (01) : 27 - 29
[44] JELLINGER K, 1986, AM J MED GENET, V24, P259
[45] The expression of methyl CpG binding factor MeCP2 correlates with cellular differentiation in the developing rat brain and in cultured cells
Jung, BP
Jugloff, DGM
Zhang, GM
Logan, R
Brown, S
Eubanks, JH
[J]. JOURNAL OF NEUROBIOLOGY, 2003, 55 (01): : 86 - 96
[46] KANNER L, 1968, ACTA PAEDOPSYCHIATR, V35, P100
[47] Predominant maternal expression of the mouse Atp10c in hippocampus and olfactory bulb
Kashiwagi, A
Meguro, M
Hoshiya, H
Haruta, M
Ishino, F
Shibahara, T
Oshimura, M
[J]. JOURNAL OF HUMAN GENETICS, 2003, 48 (04) : 194 - 198
[48] Neuropathology of infantile autism
Kemper, TL
Bauman, M
[J]. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1998, 57 (07) : 645 - 652
[49] A mutation hot spot for nonspecific X-linked mental retardation in the MECP2 gene causes the PPM-X syndrome
Klauck, SM
Lindsay, S
Beyer, KS
Splitt, M
Burn, J
Poustka, A
[J]. AMERICAN JOURNAL OF HUMAN GENETICS, 2002, 70 (04) : 1034 - 1037
[50] TARGETED DISRUPTION OF THE TRKB NEUROTROPHIN RECEPTOR GENE RESULTS IN NERVOUS-SYSTEM LESIONS AND NEONATAL DEATH
KLEIN, R
SMEYNE, RJ
WURST, W
LONG, LK
AUERBACH, BA
JOYNER, AL
BARBACID, M
[J]. CELL, 1993, 75 (01) : 113 - 122

← 1 2 3 4 5 6 7 8 9 →