Postnatal neurodevelopmental disorders: Meeting at the synapse?

被引：494

作者：

Zoghbi, HY ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Neurol, Houston, TX 77030 USA

[3] Baylor Coll Med, Dept Mol & Human Genet, Div Neurosci, Houston, TX 77030 USA

[4] Baylor Coll Med, Howard Hughes Med Inst, Houston, TX 77030 USA

来源：

SCIENCE | 2003年 / 302卷 / 5646期

关键词：

D O I：

10.1126/science.1089071

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We often think of neurodevelopmental disorders as beginning before birth, and many certainly do. A handful, however, strike many months after birth, following a period of apparently normal growth and development. Autism and Rett syndrome are two such disorders, and here I consider some of their similarities at the phenotypic and pathogenic levels. I propose that both disorders result from disruption of postnatal or experience-dependent synaptic plasticity.

引用

页码：826 / 830

页数：5

共 84 条

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