Activities of hexadecylphosphocholine (miltefosine), AmBisome, and sodium stibogluconate (Pentostam) against Leishmania donovani in immunodeficient scid mice

被引：78

作者：

Escobar, P ^{[1
]}

Yardley, V ^{[1
]}

Croft, SL ^{[1
]}

机构：

[1] Univ London London Sch Hyg & Trop Med, Dept Infect & Trop Dis, London WC1E 7HT, England

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2001年 / 45卷 / 06期

关键词：

D O I：

10.1128/AAC.45.6.1872-1875.2001

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In both scid and BALB/e mouse-Leishmartia. donovani models, hexadecyphosphocholine (miltefosine) and AmBisome had similar levels of activity. In contrast, sodium stibogluconate (Pentostam) was significantly less active against L. donovani in scid mice than in BALB/c mice. The in vitro anti-leishmanial activity of miltefosine was similar in peritoneal macrophages derived from both scid and BALB/c mice, whereas Pentostam and AmBisome were significantly more active in the latter.

引用

页码：1872 / 1875

页数：4

共 33 条

[1] Leishmania and human immunodeficiency virus coinfection: The first 10 years
Alvar, J
Canavate, C
GutierrezSolar, B
Jimenez, M
Laguna, F
LopezVelez, R
Molina, R
Moreno, J
[J]. CLINICAL MICROBIOLOGY REVIEWS, 1997, 10 (02) : 298 - +
[2] The inhibition of cell signaling pathways by antitumor ether lipids
Arthur, G
Bittman, R
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM, 1998, 1390 (01): : 85 - 102
[3] Human leishmaniasis: Clinical, diagnostic, and chemotherapeutic developments in the last 10 years
Berman, JD
[J]. CLINICAL INFECTIOUS DISEASES, 1997, 24 (04) : 684 - 703
[4] A SEVERE COMBINED IMMUNODEFICIENCY MUTATION IN THE MOUSE
BOSMA, GC
CUSTER, RP
BOSMA, MJ
[J]. NATURE, 1983, 301 (5900) : 527 - 530
[5] DISTRIBUTION AND METABOLISM OF HEXADECYLPHOSPHOCHOLINE IN MICE
BREISER, A
KIM, DJ
FLEER, EAM
DAMENZ, W
DRUBE, A
BERGER, M
NAGEL, GA
EIBL, H
UNGER, C
[J]. LIPIDS, 1987, 22 (11) : 925 - 926
[6] AMPHOTERICIN-B INDUCES TUMOR NECROSIS FACTOR PRODUCTION BY MURINE MACROPHAGES
CHIA, JKS
POLLACK, M
[J]. JOURNAL OF INFECTIOUS DISEASES, 1989, 159 (01) : 113 - 116
[7] The activities of four anticancer alkyllysophospholipids against Leishmania donovani, Trypanosoma cruzi and Trypanosoma brucei
Croft, SL
Snowdon, D
Yardley, V
[J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1996, 38 (06) : 1041 - 1047
[8] THE ACTIVITY OF ALKYL PHOSPHORYLCHOLINES AND RELATED DERIVATIVES AGAINST LEISHMANIA-DONOVANI
CROFT, SL
NEAL, RA
PENDERGAST, W
CHAN, JH
[J]. BIOCHEMICAL PHARMACOLOGY, 1987, 36 (16) : 2633 - 2636
[9] Visceral leishmaniasis in clinical practice
Davidson, RN
[J]. JOURNAL OF INFECTION, 1999, 39 (02) : 112 - 116
[10] Global control and leishmania HIV co-infection
Desjeux, P
[J]. CLINICS IN DERMATOLOGY, 1999, 17 (03) : 317 - 325

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