Genomic structure and expression of the murine Hmgi-c gene

被引：59

作者：

Zhou, XJ ^{[1
]}

Benson, KF ^{[1
]}

Przybysz, K ^{[1
]}

Liu, J ^{[1
]}

Hou, Y ^{[1
]}

Cherath, L ^{[1
]}

Chada, K ^{[1
]}

机构：

[1] UNIV MED & DENT NEW JERSEY,ROBERT WOOD JOHNSON MED SCH,DEPT BIOCHEM,PISCATAWAY,NJ 08854

来源：

NUCLEIC ACIDS RESEARCH | 1996年 / 24卷 / 20期

关键词：

D O I：

10.1093/nar/24.20.4071

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The murine Hmgi-c gene, a member of the Hmgi gene family, contains five exons encompassing >110 kb of genomic DNA at the pygmy locus on mouse chromosome 10, Northern analysis identified a 4.1 kb transcript which contains a 324 bp open reading frame encoding a 12 kDa HMGI-C protein. Further analysis defined both the 5' and 3' untranslated regions of the Hmgi-c mRNA species as 658 and 2967 bp respectively, The HMGI-C protein has three consecutive AT hook DNA binding domains and an acidic domain, each of which are encoded by individual exons; such an organization is conserved among the HMGI gene family members from insects to mammals, Similar to the HMGI/Y proteins, the HMGI-C protein does not function as a typical transcriptional activator, Developmental studies revealed that the Hmgi-c gene is expressed predominantly during mouse embryogenesis, Since the human homolog is disrupted in a number of tumors, HMGI-C could play an important role in cell proliferation and differentiation during mammalian development.

引用

页码：4071 / 4077

页数：7

共 41 条

[21] TRANSCRIPTION FACTOR ATF CDNA CLONES - AN EXTENSIVE FAMILY OF LEUCINE ZIPPER PROTEINS ABLE TO SELECTIVELY FORM DNA-BINDING HETERODIMERS
HAI, TW
LIU, F
COUKOS, WJ
GREEN, MR
[J]. GENES & DEVELOPMENT, 1989, 3 (12B) : 2083 - 2090
[22] SEQUENCE-SPECIFIC BINDING OF HUMAN ETS-1 TO THE T-CELL RECEPTOR ALPHA-GENE ENHANCER
HO, IC
BHAT, NK
GOTTSCHALK, LR
LINDSTEN, T
THOMPSON, CB
PAPAS, TS
LEIDEN, JM
[J]. SCIENCE, 1990, 250 (4982) : 814 - 818
[23] GC BOX BINDING INDUCES PHOSPHORYLATION OF SP1 BY A DNA-DEPENDENT PROTEIN-KINASE
JACKSON, SP
MACDONALD, JJ
LEESMILLER, S
TJIAN, R
[J]. CELL, 1990, 63 (01) : 155 - 165
[24] JOHN S, 1995, MOL CELL BIOL, V15, P1786
[25] ALTERNATIVE PROCESSING OF MESSENGER-RNAS ENCODING MAMMALIAN CHROMOSOMAL HIGH-MOBILITY-GROUP PROTEINS HMG-I AND HMG-Y
JOHNSON, KR
LEHN, DA
REEVES, R
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (05) : 2114 - 2123
[26] GROWTH FACTOR-INDUCED DELAYED EARLY RESPONSE GENES
LANAHAN, A
WILLIAMS, JB
SANDERS, LK
NATHANS, D
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (09) : 3919 - 3929
[27] COOPERATIVITY BETWEEN 2 NF-KAPPA-B COMPLEXES, MEDIATED BY HIGH-MOBILITY-GROUP PROTEIN-I(Y), IS ESSENTIAL FOR CYTOKINE-INDUCED EXPRESSION OF THE E-SELECTIN PROMOTER
LEWIS, H
KASZUBSKA, W
DELAMARTER, JF
WHELAN, J
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (09) : 5701 - 5709
[28] NEW LIGHT ON MYC AND MYB .2. MYB
LUSCHER, B
EISENMAN, RN
[J]. GENES & DEVELOPMENT, 1990, 4 (12B) : 2235 - 2241
[29] A NEW CLASS OF YEAST TRANSCRIPTIONAL ACTIVATORS
MA, J
PTASHNE, M
[J]. CELL, 1987, 51 (01) : 113 - 119
[30] CDNA CLONING OF THE HMGI-C PHOSPHOPROTEIN, A NUCLEAR-PROTEIN ASSOCIATED WITH NEOPLASTIC AND UNDIFFERENTIATED PHENOTYPES
MANFIOLETTI, G
GIANCOTTI, V
BANDIERA, A
BURATTI, E
SAUTIERE, P
CARY, P
CRANEROBINSON, C
COLES, B
GOODWIN, GH
[J]. NUCLEIC ACIDS RESEARCH, 1991, 19 (24) : 6793 - 6797

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