MIC and other NKG2D ligands: from none to too many

被引：81

作者：

Bahram, S

Inoko, H

Shiina, T

Radosavljevic, M

机构：

[1] Hop Univ Strasbourg, Ctr Rech Immunol & Hemat, Fac Med, F-67085 Strasbourg, France

[2] Hop Univ Strasbourg, Lab Cent Immunol, F-67085 Strasbourg, France

[3] Tokai Univ, Sch Med, Dept Basic Med Sci, Kanagawa 2591143, Japan

[4] Tokai Univ, Sch Med, Dept Mol Med, Kanagawa 2591143, Japan

来源：

CURRENT OPINION IN IMMUNOLOGY | 2005年 / 17卷 / 05期

基金：

日本学术振兴会;

关键词：

D O I：

10.1016/j.coi.2005.07.016

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

NKG2D, a prime activatory receptor on human NK, CD8(+) alpha beta and gamma delta cells, has a variety of ligands, which, despite sharing membership of the MHC class I structural club, display an array of unique features. Chronologically, human MIC molecules were the first NKG2D ligands to be identified. Then came RAET1 (ULBP) molecules, which were identified in both man and mouse, as well as H60 and MULT1, which have no counterparts in man to date. The question remains as to why, more than how, the evolutionary conserved, apparently monomorphic, single copy, NKG2D, can/should adapt to this variety of ligands, and when it does, what is the evolutionary advantage of this profusion of ligands for a single receptor?.

引用

页码：505 / 509

页数：5

共 53 条

[1] Identification of a novel HLA-B allele (B*4202) in a Saudi Arabian family with Behcet's disease
Ando, H
Mizuki, N
Ohno, S
Tabbara, KF
Taguchi, S
Yamazaki, M
Mizuki, N
Miyata, Y
Wakisaka, K
Inoko, H
[J]. TISSUE ANTIGENS, 1997, 49 (05): : 526 - 528
[2] Comparative sequencing of human and chimpanzee MHC class I regions unveils insertions/deletions as the major path to genomic divergence
Anzai, T
Shiina, T
Kimura, N
Yanagiya, K
Kohara, S
Shigenari, A
Yamagata, T
Kulski, JK
Naruse, TK
Fujimori, Y
Fukuzumi, Y
Yamazaki, M
Tashiro, H
Iwamoto, C
Umehara, Y
Imanishi, T
Meyer, A
Ikeo, K
Gojobori, T
Bahram, S
Inoko, H
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (13) : 7708 - 7713
[3] Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D
Bacon, L
Eagle, RA
Meyer, M
Easom, N
Young, NT
Trowsdale, J
[J]. JOURNAL OF IMMUNOLOGY, 2004, 173 (02) : 1078 - 1084
[4] A 2ND LINEAGE OF MAMMALIAN MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I GENES
BAHRAM, S
BRESNAHAN, M
GERAGHTY, DE
SPIES, T
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (14) : 6259 - 6263
[5] Bahram S, 2000, Adv Immunol, V76, P1
[6] HLA class I, NKG2D, and natural cytotoxicity receptors regulate multiple myeloma cell recognition by natural killer cells
Carbone, E
Neri, P
Mesuraca, M
Fulciniti, MT
Otsuki, T
Pende, D
Groh, V
Spies, T
Pollio, G
Cosman, D
Catalano, L
Tassone, P
Rotoli, B
Venuta, S
[J]. BLOOD, 2005, 105 (01) : 251 - 258
[7] NKG2D ligands: unconventional MHC class I-like molecules exploited by viruses and cancer
Cerwenka, A
Lanier, LL
[J]. TISSUE ANTIGENS, 2003, 61 (05): : 335 - 343
[8] ULBP4 is a novel ligand for human NKG2D
Chalupny, NJ
Sutherland, CL
Lawrence, WA
Rein-Weston, A
Cosman, D
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 305 (01) : 129 - 135
[9] Cosman D, 2001, IMMUNITY, V14, P123, DOI 10.1016/S1074-7613(01)00095-4
[10] Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D
Diefenbach, A
Tomasello, E
Lucas, M
Jamieson, AM
Hsia, JK
Vivier, E
Raulet, DH
[J]. NATURE IMMUNOLOGY, 2002, 3 (12) : 1142 - 1149

← 1 2 3 4 5 6 →